All Phenotypes Tg(Hoxd9/lacZ/neo)4Ddu MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hoxd^tm11Ddu/Hoxd⁺ Tg(Hoxd9/lacZ/neo)4Ddu/0	involves: 129S2/SvPas	MGI:4361583
tg2	Tg(Hoxd9/lacZ/neo)4Ddu/Tg(Hoxd9/lacZ/neo)4Ddu	involves: 129S2/SvPas	MGI:2664911

Allelic Composition	Hoxd^tm11Ddu/Hoxd⁺ Tg(Hoxd9/lacZ/neo)4Ddu/0
Genetic Background	involves: 129S2/SvPas

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Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:82850 )

• some mice carrying both mutant loci in trans lack the joint between P1 and P2 in digit III

• all forelimbs of mice carrying both mutant loci in trans exhibit a supernumerary postaxial bony element

abnormal phalanx morphology ( J:82850 )

• mice carrying both mutant loci in trans show loss of phalange 2 in digit II

• most mice carrying both mutant loci in trans lose phalange 2 in digit V

abnormal metatarsal bone morphology ( J:82850 )

• the first metatarsal of hindlimbs is dysmorphic in mice carrying both mutant loci in trans, with an aberrantly thick and shorter aspect, and is occasionally fused to P1

skeleton

abnormal phalanx morphology ( J:82850 )

• mice carrying both mutant loci in trans show loss of phalange 2 in digit II

• most mice carrying both mutant loci in trans lose phalange 2 in digit V

abnormal metatarsal bone morphology ( J:82850 )

• the first metatarsal of hindlimbs is dysmorphic in mice carrying both mutant loci in trans, with an aberrantly thick and shorter aspect, and is occasionally fused to P1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

increased hindlimb autopod size ( J:82850 )

• thickening of the anterior hindpaw at the basis of the first digit

abnormal digit morphology ( J:82850 )

• in digit II, the joint between phalange 2 and phalange 1 is frequently lost or incompletely developed

• mutants often exhibit a supernumerary postaxial bony element

abnormal phalanx morphology ( J:82850 )

• in some cases, the second phalange is lost in digit V

brachyphalangia ( J:82850 )

• shortening of the second phalanges of digits II and V in the forelimbs

brachydactyly ( J:82850 )

• shortening of the 2nd and 5th digits in the forelimbs

ectrodactyly ( J:82850 )

• truncation of the second and fifth digits due to shorter second phalanges and sometimes loss of the second phalange in the fifth digit

abnormal metatarsal bone morphology ( J:82850 )

• in hind limbs, the first metatarsal bone is abnormally thicker and shorter in size

reproductive system

male infertility ( J:82850 )

skeleton

abnormal phalanx morphology ( J:82850 )

• in some cases, the second phalange is lost in digit V

brachyphalangia ( J:82850 )

• shortening of the second phalanges of digits II and V in the forelimbs

abnormal metatarsal bone morphology ( J:82850 )

• in hind limbs, the first metatarsal bone is abnormally thicker and shorter in size

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