Phenotypes associated with this allele

• Allele Symbol: Tg(CMV-GAL4)1Shy
• Allele Name: transgene insertion 1, G Shyamala
• Allele ID: MGI:2656724
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(CMV-GAL4)1Shy/0 Tg(Pgr)2Shy/0	Not Specified	MGI:2656730
cx2	Tg(CMV-GAL4)1Shy/0 Tg(Pgr)3Shy/0	Not Specified	MGI:2657222

Genotype
MGI:2656730

cx1

• Allelic Composition: Tg(CMV-GAL4)1Shy/0; Tg(Pgr)2Shy/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland duct morphology ( J:45538 )

♀ • tips of ducts show clustered buds compared to the smooth structure characteristic of normal terminal ducts

♀ • some ducts show regions with indistinct epithelial-stromal boundary and multiple branched outgrowths of disorganized epithelial cell masses at the tips

♀ • thickening of the mammary gland duct wall due to multilayered composition of the wall with a disorganized basement membrane and decreased cell-cell adhesion

♀ • mammary gland end buds with unusual morphology persist in ovariectomized prepubertal mice; these end buds have unusual fibrous caps and the continuity of cap cells is disrupted

abnormal branching of the mammary ductal tree ( J:45538 )

♀ • mammary glands of young adult nonovariectomized mice exhibit extensive lateral branching

♀ • ducts exhibit increased numbers of buds growing from what are normally growth-quiescent zones

mammary gland duct hyperplasia ( J:45538 )

♀ • ductal hyperplasia and extensive lateral branching

integument

abnormal mammary gland duct morphology ( J:45538 )

♀ • tips of ducts show clustered buds compared to the smooth structure characteristic of normal terminal ducts

♀ • some ducts show regions with indistinct epithelial-stromal boundary and multiple branched outgrowths of disorganized epithelial cell masses at the tips

♀ • thickening of the mammary gland duct wall due to multilayered composition of the wall with a disorganized basement membrane and decreased cell-cell adhesion

♀ • mammary gland end buds with unusual morphology persist in ovariectomized prepubertal mice; these end buds have unusual fibrous caps and the continuity of cap cells is disrupted

abnormal branching of the mammary ductal tree ( J:45538 )

♀ • mammary glands of young adult nonovariectomized mice exhibit extensive lateral branching

♀ • ducts exhibit increased numbers of buds growing from what are normally growth-quiescent zones

mammary gland duct hyperplasia ( J:45538 )

♀ • ductal hyperplasia and extensive lateral branching

Genotype
MGI:2657222

cx2

• Allelic Composition: Tg(CMV-GAL4)1Shy/0; Tg(Pgr)3Shy/0
• Genetic Background: Not Specified

endocrine/exocrine glands

abnormal mammary gland development ( J:83103 )

♀ • in about 20% of mutants, the fat pad in mammary glands is not completely filled, no lateral branching is observed, and even in the absence of fat pad filling, glands do not contain any end-buds, indicating cessation of growth

♀ • mammary glands, on serial transplantation, undergo premature arrest in ductal growth without alterations in lobulo-alveolar growth

integument

abnormal mammary gland development ( J:83103 )

♀ • in about 20% of mutants, the fat pad in mammary glands is not completely filled, no lateral branching is observed, and even in the absence of fat pad filling, glands do not contain any end-buds, indicating cessation of growth

♀ • mammary glands, on serial transplantation, undergo premature arrest in ductal growth without alterations in lobulo-alveolar growth