Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ctnnb1Bfc batface MGI:2656734 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no viable mice are generated
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• all mice exhibit head reduction defects unlike wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are produced
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• mice exhibit ocular defects that are more prominent on a background with C57BL/6 compared with BALB/c
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• 38% of mice at E8-9.0 and 90% of mice at E9-10 exhibit head defects with reduced forebrain unlike wild-type mice
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• squashed snout
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• 38% of mice at E8-9.0 and 90% of mice at E9-10 exhibit head defects with reduced forebrain unlike wild-type mice
• 23% of mice exhibit reduced head tissue compared with wild-type mice
• at E9.0 to E10.0, 27% of mice exhibit head defects compared with 2% of wild-type mice
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• squashed snout
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• broad face
(J:63816)
• the anteroposterior axis was significantly shortened, whereas the dorsoventral and medial-lateral axes were enlarged
(J:209611)
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• wide-spaced eyes
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• broad face
(J:63816)
• the anteroposterior axis was significantly shortened, whereas the dorsoventral and medial-lateral axes were enlarged
(J:209611)
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• gray matter and total brain volumes were significantly larger in Bfc/+ (P < 0.05; 1-way ANOVA)
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• the corpus callosum appeared to be severely underdeveloped in 3 Bfc/+ individuals, and lacked any inter-hemispheric extensions
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• globus pallidus is slightly, but significantly, larger in Bfc/+
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• striatum is slightly, but significantly, larger in Bfc/+
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• thalamus is slightly, but significantly, larger in Bfc/+
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• the length and number of neurites were significantly increased after only 1 day in culture
• after 8 days in culture, the extent of dendritic branching in heterozygous neurons was dramatically lower than in controls
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• mutants showed substantially reduced cerebellar and olfactory bulb volumes compared with controls
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• mutants showed substantially reduced cerebellar and olfactory bulb volumes compared with controls
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• heterozygotes, a lower density of docked synaptic vesicles (SV) in cortex and in hippocampus CA1 region is seen
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• long-term potentiation (LTP) induced by either tetanic or theta-burst stimulation was significantly reduced in hippocampus CA1 slices from heterozygous mice
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• heterozygous mice mice show significant PPI deficits but acoustic startle response is comparable to controls
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• freezing behavior in heterozygous mice using a standard fear conditioning protocol for contextual memory is significantly lower than that of littermate controls, suggesting that mutants have a reduced capacity to recall the previous shock exposure
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• for trials in which rewards are given after a light event, responses increase significantly during the expected time interval in control mice, but not in heterozygous mutants
• in probe trials where no reward is given, responses of heterozygous mutant mice during the critical time window is significantly lower than littermate controls
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• control animals improve performance with repeated trials in the hidden platform variation of the water maze test, but heterozygous mutant mice did not improve
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• heterozygous mice show a significantly shorter latency period before falling from the rod in a challenging rotarod test incorporaing 6 consecutive accelerating stages in a single session; no differences are seen in a standard rotarod test
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• heterozygous pups exhibit a significant reduction in the total number of vocalizations with more of these calls characterized by a single component compared to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 23% of mice exhibit complete head truncation unlike wild-type mice
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• all mice exhibit head reduction defects unlike wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 86% of mice exhibit head reduction defects unlike wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are produced
• viability is less than in Ctnnb1Bfc heterozygotes
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• ocular defects are higher than in Ctnnb1Bfc heterozygotes
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• 92% of mice exhibit head defects compared with wild-type mice
• head defects are higher than in Ctnnb1Bfc heterozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mice exhibit head reduction defects unlike wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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