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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Erbb2tm1Mll
targeted mutation 1, Ulrich Muller
MGI:2656906
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Erbb2tm3(Erbb2)Mul/Erbb2tm1Mll
Tg(ACTA1-cre)1Mll/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2656909
cn2
 		Erbb2tm1Mll/Erbb2tm1Mll
Erbb4tm1Fej/Erbb4tm1Fej
Tg(Gabra6-cre)CWwis/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3836815


Genotype
MGI:2656909
cn1
Allelic
Composition		 Erbb2tm3(Erbb2)Mul/Erbb2tm1Mll
Tg(ACTA1-cre)1Mll/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Mll mutation (1 available); any Erbb2 mutation (61 available)
Erbb2tm3(Erbb2)Mul mutation (0 available); any Erbb2 mutation (61 available)
Tg(ACTA1-cre)1Mll mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal motor capabilities/coordination/movement ( J:82801 )
• when placed on a slippery surface, mutants are unable to position their limbs properly
• mutants exhibit spastic movements
abnormal reflex ( J:82801 )
• abnormal hindlimb extension reflexes

muscle
abnormal muscle spindle morphology ( J:82801 )
• initial contact between sensory Ia afferent neurons and myotubes occurs but subsequent development of muscle spindles is impaired
absent muscle spindles ( J:82801 )
• absence of muscle spindles

nervous system
abnormal muscle spindle morphology ( J:82801 )
• initial contact between sensory Ia afferent neurons and myotubes occurs but subsequent development of muscle spindles is impaired
absent muscle spindles ( J:82801 )
• absence of muscle spindles
abnormal neuromuscular synapse morphology ( J:82801 )
• synapses at neuromuscular junctions contain reduced numbers of acetylcholine receptors
abnormal CNS synaptic transmission ( J:82801 )
• mutants exhibit reduced synaptic transmission at neuromuscular junctions; mepc amplitudes are reduced by about 15% compared to wild-type




Genotype
MGI:3836815
cn2
Allelic
Composition		 Erbb2tm1Mll/Erbb2tm1Mll
Erbb4tm1Fej/Erbb4tm1Fej
Tg(Gabra6-cre)CWwis/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Mll mutation (1 available); any Erbb2 mutation (61 available)
Erbb4tm1Fej mutation (1 available); any Erbb4 mutation (87 available)
Tg(Gabra6-cre)CWwis mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:145947 )
N
• no gross morphological defects in the cerebellum at 4 months
• multiple climbing fiber innervation of Purkinje cells does not persist




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory