Analysis Tools|
Allele Symbol Allele Name Allele ID |
Socs1tm3Wehi targeted mutation 3, Walter and Eliza Hall Institute of Medical Research MGI:2656917 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• enlarged thymic medulla
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• increase in thymus cellularity predominately due to an increase in CD8+ T cell population
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• enhanced differentiation of thymocytes toward CD8+ T cells
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• large reduction in the percentage of non-T cells, mostly B cells, in the lymph nodes
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• increase in the ratio of mature CD8 single positive:CD4 single positive thymocytes from 1:4 to 1:1
• increase in the ratio of CD8+:CD4+ T cells in the spleen, however total numbers of T cells are unchanged
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• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size
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• increase in CD4+ T cells in the blood
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• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size
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• large increase in the percentage and number of CD8 single positive thymocytes at 6 weeks of age
• increase in CD8+ T cells in the blood
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• almost all peripheral CD8+ T cells but not CD4+ T cells appear as CD44ho, indicating that they exhibit a memory rather than activated phenotype
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• lymph nodes contain 2-fold the number of cells in controls
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• enlarged thymic medulla
|
|
• increase in thymus cellularity predominately due to an increase in CD8+ T cell population
|
|
• enhanced differentiation of thymocytes toward CD8+ T cells
|
|
• large reduction in the percentage of non-T cells, mostly B cells, in the lymph nodes
|
|
• increase in the ratio of mature CD8 single positive:CD4 single positive thymocytes from 1:4 to 1:1
• increase in the ratio of CD8+:CD4+ T cells in the spleen, however total numbers of T cells are unchanged
|
|
• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size
|
|
• increase in CD4+ T cells in the blood
|
|
• mature thymocytes, both CD4 single positive and CD8 single positive, are larger in size
|
|
• large increase in the percentage and number of CD8 single positive thymocytes at 6 weeks of age
• increase in CD8+ T cells in the blood
|
|
• almost all peripheral CD8+ T cells but not CD4+ T cells appear as CD44ho, indicating that they exhibit a memory rather than activated phenotype
|
|
• enlarged thymic medulla
|
|
• increase in thymus cellularity predominately due to an increase in CD8+ T cell population
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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