Phenotypes associated with this allele

• Allele Symbol: Por^tm2Wolf
• Allele Name: targeted mutation 2, C Roland Wolf
• Allele ID: MGI:2656920
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Por^tm2Wolf/Por^tm1Wolf Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:2656921

Genotype
MGI:2656921

cn1

• Allelic Composition: Por^tm2Wolf/Por^tm1Wolf; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

enlarged liver ( J:82951 )

• liver almost doubled in size

homeostasis/metabolism

decreased circulating cholesterol level ( J:82951 )

• 65% reduction in serum cholesterol

decreased circulating triglyceride level ( J:82951 )

• 50% reduction in serum triglyceride level

increased circulating alanine transaminase level ( J:82951 )

abnormal bile salt level ( J:82951 )

• 90% reduction in bile acid volume in the gall bladder

abnormal xenobiotic pharmacokinetics ( J:82951 )

• altered metabolism of pentobarbital and acetominophen

abnormal acetaminophen metabolism ( J:82951 )

liver/biliary system

enlarged liver ( J:82951 )

• liver almost doubled in size

macrovesicular hepatic steatosis ( J:82951 )

• macrovesicular fatty changes

microvesicular hepatic steatosis ( J:82951 )

• microvesicular fatty changes

pale liver ( J:82951 )

reproductive system

reduced fertility ( J:82951 )

• reduced fertility when mated with other null animals

decreased litter size ( J:82951 )

• reduced litter size when mated with other null animals