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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgfr1tm1.1Jpa
targeted mutation 1.1, Juha Partanen
MGI:2657013
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR MGI:2657015
cn2
 		Fgfr1tm1.1Jpa/Fgfr1+
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+
Tg(Prrx1-cre)1Cjt/0 		involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster MGI:3848913
cn3
 		Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2+
Twist2tm1(cre)Dor/Twist2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3813483
cn4
 		Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2tm1.1Dor
Twist2tm1(cre)Dor/Twist2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3813486
cn5
 		Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR MGI:3703447
cx6
 		Fgfr1tm1.1Jpa/Fgfr1+
Spry2tm1.1Mrt/Spry2tm1.1Mrt 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3702559


Genotype
MGI:2657015
hm1
Allelic
Composition		 Fgfr1tm1.1Jpa/Fgfr1tm1.1Jpa
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal gastrulation ( J:83004 )
• gastrulation defects




Genotype
MGI:3848913
cn2
Allelic
Composition		 Fgfr1tm1.1Jpa/Fgfr1+
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal limb development ( J:149478 )
• at P1, mice exhibit a more severe zeugopod phenotypes than in Gt(ROSA)26Sortm5(Etv4/en,-GFP)Amc/Gt(ROSA)26Sor+ Tg(Prrx1-cre)1Cjt mice




Genotype
MGI:3813483
cn3
Allelic
Composition		 Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2+
Twist2tm1(cre)Dor/Twist2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal small intestine morphology ( J:139005 )
• there is about a 15% reduction in the length of the small intestine at E18.5 compared to controls




Genotype
MGI:3813486
cn4
Allelic
Composition		 Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
Fgfr2tm1Dor/Fgfr2tm1.1Dor
Twist2tm1(cre)Dor/Twist2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2tm1.1Dor mutation (0 available); any Fgfr2 mutation (90 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal small intestine morphology ( J:139005 )
• there is about a third reduction in the length of the small intestine at E18.5 compared to controls
abnormal small intestine crypts of Lieberkuhn morphology ( J:139005 )
• premature crypt-like structures occur in the small intestine of E18.5 embryos before the appearance of paneth cells
abnormal digestive system physiology ( J:139005 )
• proliferation of fibroblasts found in the proximal and distal small intestine mesenchyme is significantly reduced at E18.5

endocrine/exocrine glands
abnormal small intestine crypts of Lieberkuhn morphology ( J:139005 )
• premature crypt-like structures occur in the small intestine of E18.5 embryos before the appearance of paneth cells




Genotype
MGI:3703447
cn5
Allelic
Composition		 Fgfr1tm1Jpa/Fgfr1tm1.1Jpa
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:81179 )
N
• at E9.5, no defects are seen in the early development of the second branchial arch unlike mice homozygous for Fgfr1tm2Jrt
abnormal craniofacial bone morphology ( J:81179 )
• no enhancement in later craniofacial phenotypes relative to mice homozygous for Fgfr1tm1Jrt that carry the Tg(Wnt1-cre)11Rth transgene

digestive/alimentary system

skeleton
abnormal craniofacial bone morphology ( J:81179 )
• no enhancement in later craniofacial phenotypes relative to mice homozygous for Fgfr1tm1Jrt that carry the Tg(Wnt1-cre)11Rth transgene

growth/size/body
cleft palate ( J:81179 )




Genotype
MGI:3702559
cx6
Allelic
Composition		 Fgfr1tm1.1Jpa/Fgfr1+
Spry2tm1.1Mrt/Spry2tm1.1Mrt
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1.1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Spry2tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
supernumerary teeth ( J:119280 )
• frequency of diastema tooth formation is reduced to 60% compared to almost 100% in mice homozygous for the Spry2 allele alone

growth/size/body
supernumerary teeth ( J:119280 )
• frequency of diastema tooth formation is reduced to 60% compared to almost 100% in mice homozygous for the Spry2 allele alone

skeleton
supernumerary teeth ( J:119280 )
• frequency of diastema tooth formation is reduced to 60% compared to almost 100% in mice homozygous for the Spry2 allele alone




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory