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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnmt1tm3Jae
targeted mutation 3, Rudolf Jaenisch
MGI:2657151
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnmt1tm3Jae/Dnmt1tm3Jae involves: 129S4/SvJae * BALB/c MGI:2657157
ht2
 		Dnmt1tm3Jae/Dnmt1tm2Enl involves: 129S4/SvJae * BALB/c MGI:2657159


Genotype
MGI:2657157
hm1
Allelic
Composition		 Dnmt1tm3Jae/Dnmt1tm3Jae
Genetic
Background		 involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm3Jae mutation (1 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:83179 )
• mice were viable and normal in size
• normal methylation and expression patterns of imprinted genes




Genotype
MGI:2657159
ht2
Allelic
Composition		 Dnmt1tm3Jae/Dnmt1tm2Enl
Genetic
Background		 involves: 129S4/SvJae * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm2Enl mutation (1 available); any Dnmt1 mutation (112 available)
Dnmt1tm3Jae mutation (1 available); any Dnmt1 mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:82979 )
• 80% developed aggressive thymic tumors by 4 to 8 months of age
• high frequency of chromosome 15 trisomy

growth/size/body
postnatal growth retardation ( J:82979 )
• neonates were approximately 70% the weight of Dnmt1tm2Enl heterozygotes

reproductive system
reproductive system phenotype ( J:82979 )
N
• mice were fertile




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory