All Phenotypes Trpc2<tm1Dlc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpc2^tm1Dlc/Trpc2^tm1Dlc	involves: 129S1/Sv	MGI:5461714
hm2	Trpc2^tm1Dlc/Trpc2^tm1Dlc	involves: 129S1/Sv * C57BL/6	MGI:2657155
cx3	Trpc2^tm1Dlc/Trpc2^tm1Dlc Trpc3^tm1.1Bmil/Trpc3^tm1.1Bmil	involves: 129S1/Sv * FVB/N	MGI:5461713

Allelic Composition	Trpc2^tm1Dlc/Trpc2^tm1Dlc
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc2^tm1Dlc mutation (1 available); any Trpc2 mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal erythroblast morphology ( J:189490 )

• in response to oxidative stress, erythroblasts exhibit decreased intracellular calcium compared with wild-type cells

increased hematocrit ( J:189490 )

decreased mean corpuscular hemoglobin concentration ( J:189490 )

increased mean corpuscular volume ( J:189490 )

abnormal erythrocyte physiology ( J:189490 )

• red blood cells are resistant to phenylhydrazine-induced hemolysis compared with wild-type cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

submission towards male mice ( J:74988 )

• absence of pheromone-induced aggression towards intruding males

abnormal mating preference ( J:74988 )

• males show indiscriminate mating behavior, mounting both male and female animals

nervous system

abnormal vomeronasal organ morphology ( J:74988 )

• at 2 months of age, mutants have 50% fewer V1R-V3R neurons and 75% fewer V2R neurons

abnormal accessory olfactory bulb morphology ( J:74988 )

• loss of sensory afferents to the accessory olfactory bulb at 1 month of age

abnormal sensory neuron innervation pattern ( J:74988 )

• progressive loss of axon projections in the vomeronasal organ

abnormal nervous system electrophysiology ( J:74988 )

• vomeronasal sensory neurons do not not respond to urine phermones; waveform recorded in vomeronasal organ shows spontaneous firing but not stimulus-driven change in rate

respiratory system

abnormal vomeronasal organ morphology ( J:74988 )

• at 2 months of age, mutants have 50% fewer V1R-V3R neurons and 75% fewer V2R neurons

craniofacial

abnormal vomeronasal organ morphology ( J:74988 )

• at 2 months of age, mutants have 50% fewer V1R-V3R neurons and 75% fewer V2R neurons

growth/size/body

abnormal vomeronasal organ morphology ( J:74988 )

• at 2 months of age, mutants have 50% fewer V1R-V3R neurons and 75% fewer V2R neurons

Allelic Composition	Trpc2^tm1Dlc/Trpc2^tm1Dlc Trpc3^tm1.1Bmil/Trpc3^tm1.1Bmil
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpc2^tm1Dlc mutation (1 available); any Trpc2 mutation (98 available)
Trpc3^tm1.1Bmil mutation (0 available); any Trpc3 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal erythroblast morphology ( J:189490 )

• in response to oxidative stress, erythroblasts exhibit decreased intracellular calcium compared with wild-type cells

increased hematocrit ( J:189490 )

decreased mean corpuscular hemoglobin concentration ( J:189490 )

increased mean corpuscular volume ( J:189490 )

abnormal erythrocyte physiology ( J:189490 )

• red blood cells are resistant to phenylhydrazine-induced hemolysis compared with wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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