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Allele Symbol Allele Name Allele ID |
Il4ratm1Fbb targeted mutation 1, Frank Brombacher MGI:2657172 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• exhibited increased resistance to Leishmania major infection relative to BALB/c control mice
• during further course of infection mice developed progressive disease symptoms, whereas C57BL/6 mice and Il4-null BALB/c mice cleared the infection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice succumb to Schistosoma infection in ~59 days
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• progressive weight loss begins 6 weeks after S. mansoni infection; some animals lose 20% of original body weight
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• in stimulated T cells
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• mice demonstrate a dominant Th1 response to Schistosoma characterized by Ifng production
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• livers show impaired alternative macrophage activation compared to wild-type
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• livers show impaired macrophage recruitment after Schistosoma infection
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• serum levels increase less than for controls after azoxymethane treatment
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• elevated levels after azoxymethane treatment relative to controls
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• mice have reduced Il-4, Il-5 and Il-10 production
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• there is less cell recruitment than in wild-type liver granulomas; granuloma size and eosinophil content is decreased compared to wild-type or conditional mutant mice; intestinal granulomas show massive inflammatory cell infiltration
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• granuloma form
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• mice show impaired response to N. brasiliensis, with reduced goblet cell production, reduced worm expulsion and decreased Th2 response
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• all mice die from Schistosoma infection with a mean survival time of 59 days, but all controls survive entire 80 days of monitoring
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• granuloma form
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• small but significant decline in epithelial cell proliferation
• decrease in the total epithelial cell/colifrectal crypt ratio
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• the number of aberrant crypt foci in mice treated with azoxymethane is significantly higher than in similarly treated controls
• size of foci is smaller than controls but not significantly
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• serum levels increase less than for controls after azoxymethane treatment
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• elevated levels after azoxymethane treatment relative to controls
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• significantly higher TGF beta1 intestinal epithelial cell levels after azoxymethane treatment
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• in stimulated T cells
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• livers show impaired alternative macrophage activation compared to wild-type
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• livers show impaired macrophage recruitment after Schistosoma infection
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• livers show impaired macrophage recruitment after Schistosoma infection
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• the number of aberrant crypt foci in mice treated with azoxymethane is significantly higher than in similarly treated controls
• size of foci is smaller than controls but not significantly
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice succumb to Schistosoma infection in ~54 days
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• progressive weight loss begins 6 weeks after S. mansoni infection; some animals lose 20% of original body weight
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• mice show a similar Th1 response to Il4ra-null mice and a Th2 response similar to wild-type in response to Schistosoma infection
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• livers show impaired alternative macrophage activation compared to wild-type
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• granulomas are similar to wild-type, but slightly larger and less compact: intestinal granulomas show massive inflammatory cell infiltration
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• granulomas form
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• mice develop protective immunity against Nippostrongylus brasiliensis, accompanied by Th2 development
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• mice show 100% mortality during acute infection by Schistosoma mansoni; mean survival time is 54 days
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• granulomas form
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• level of fibrosis is similar to wild-type
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• during infection by N. brasiliensis, mice develop goblet cell hyperplasis
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• livers show impaired alternative macrophage activation compared to wild-type
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• during infection by N. brasiliensis, mice develop goblet cell hyperplasis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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