Phenotypes associated with this allele

• Allele Symbol: Thrb^tm2Df
• Allele Name: targeted mutation 2, Douglas Forrest
• Allele ID: MGI:2657173
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thrb^tm2Df/Thrb^tm2Df	involves: 129S1/Sv * C57BL/6J	MGI:2657174

Genotype
MGI:2657174

hm1

• Allelic Composition: Thrb^tm2Df/Thrb^tm2Df
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina cone cell morphology ( J:66737 )

• absence of M-cones (middle wavelength, green) and an increase in S-cones (short wavelength, blue)

• S-cones are spread throughout the retina

abnormal cone electrophysiology ( J:66737 )

• electroretinograms show reduced sensitivity to longer waves (600 nm)

nervous system

abnormal retina cone cell morphology ( J:66737 )

• absence of M-cones (middle wavelength, green) and an increase in S-cones (short wavelength, blue)

• S-cones are spread throughout the retina

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:66737 )

N • mutants display normal auditory-evoked brainstem responses

homeostasis/metabolism

increased circulating triiodothyronine level ( J:66737 )

• serum T3 levels are slightly elevated

increased circulating thyroid-stimulating hormone level ( J:66737 )

• serum TSH levels are slightly elevated