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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sptbn4Gt(ROSABetageo)62Sor
gene trap 62, Philippe Soriano
MGI:2657204
Summary 3 genotypes


Genotype
MGI:3710616
hm1
Allelic
Composition
Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic
Background
129S4/SvJaeSor-Spnb4Gt(ROSABetageo)62Sor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbn4Gt(ROSABetageo)62Sor mutation (1 available); any Sptbn4 mutation (122 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• first observable at weaning, continue and worsen with age
• mice cannot walk at 6-10 months of age

muscle
• mice 6-10 months of age exhibit continuous contraction of hind limb skeletal muscle




Genotype
MGI:3710617
hm2
Allelic
Composition
Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic
Background
B6.129S4-Sptbn4Gt(ROSABetageo)62Sor/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbn4Gt(ROSABetageo)62Sor mutation (1 available); any Sptbn4 mutation (122 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• first observable at weaning, continue and worsen with age
• mice cannot walk at 6-10 months of age

muscle
• mice 6-10 months of age exhibit continuous contraction of hind limb skeletal muscle




Genotype
MGI:3710606
hm3
Allelic
Composition
Sptbn4Gt(ROSABetageo)62Sor/Sptbn4Gt(ROSABetageo)62Sor
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbn4Gt(ROSABetageo)62Sor mutation (1 available); any Sptbn4 mutation (122 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• first observable at weaning, continue and worsen with age
• mice cannot walk at 6-10 months of age
• males reproduce very inefficiently when mated with wild-type females
• however, no histological abnormalities are detected and when mating occurs normal litter sizes are produced

muscle
• mice 6-10 months of age exhibit continuous contraction of hind limb skeletal muscle (J:77228)
• at older than 8 months mice often exhibit continuous contraction of hindleg muscle (J:120916)

nervous system
• ankyrin G+ regions of the neurons, but not Purkinje cells, in the cerebral cortex are longer
• plasma membranes at the Node of Ranvier in the optic nerve are wavy and swollen





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory