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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Jag2tm1Grid
targeted mutation 1, Tom Gridley
MGI:2657215
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Jag2tm1Grid/Jag2tm1Grid involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J MGI:3776433
hm2
Jag2tm1Grid/Jag2tm1Grid involves: 129S1/Sv * C57BL/6J MGI:2657216
ht3
Jag2tm1Grid/Jag2+ involves: 129S1/Sv * C57BL/6J MGI:3691117
cx4
Dll1tm1Gos/Dll1tm2Gos
Jag2tm1Grid/Jag2tm1Grid
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J MGI:3776435
cx5
Dll1tm1Gos/Dll1+
Jag2tm1Grid/Jag2+
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J MGI:3776431
cx6
Dll1tm1Gos/Dll1+
Jag2tm1Grid/Jag2tm1Grid
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J MGI:3776434
cx7
Dll1tm2Gos/Dll1+
Jag2tm1Grid/Jag2+
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J MGI:3776430
cx8
Jag2tm1Grid/Jag2tm1Grid
Lfngtm1Grid/Lfng+
involves: 129S1/Sv * C57BL/6J MGI:3696038
cx9
Jag2tm1Grid/Jag2tm1Grid
Lfngtm1Grid/Lfngtm1Grid
involves: 129S1/Sv * C57BL/6J MGI:3696037


Genotype
MGI:3776433
hm1
Allelic
Composition
Jag2tm1Grid/Jag2tm1Grid
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice do not survive postnatally

hearing/vestibular/ear
• hair cell stereocilia bundles exhibit some disorganization

nervous system
• hair cell stereocilia bundles exhibit some disorganization




Genotype
MGI:2657216
hm2
Allelic
Composition
Jag2tm1Grid/Jag2tm1Grid
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all homozygotes die within a few minutes after birth because of craniofacial defects

respiratory system
• most newborn homozygotes are unable to breathe
• only a few are able to breathe, but all of these die within a few hours after birth with large amounts of air in the stomach and intestines

homeostasis/metabolism
• newborn homozygotes become rapidly cyanotic

craniofacial
• at E18 (~1 day prior to birth), homozygotes display fusion of the tongue with the unelevated palatal shelves, preventing proper formation of the oral cavity
• at E18 (~1 day prior to birth), all homozygotes display a bilateral cleft of the secondary palate
• palatal shelves fail to elevate and fuse in the dorsal midline

embryo
• at E10.5-E11.5, homozygotes display a hyperplastic AER
• however, no decreased AER programmed cell death is noted at E10.5

limbs/digits/tail
• at E10.5-E11.5, homozygotes display a hyperplastic AER
• however, no decreased AER programmed cell death is noted at E10.5
• 5 of 13 newborn homozygotes show primary chondrogenic or secondary osseous fusions of the distal phalanges, with the hindfeet more severely affected
• several newborns exhibit splitting of the terminal phalanx of digit 2 of the hindfeet
• newborn homozygotes exhibit syndactyly of the fore- and hindlimbs
• syndactyly is associated with reduced interdigital cell death in digits 2, 3, and 4, and often involves soft tissue fusions
• hindlimbs are more severely affected than forelimbs
• at E13.5, mutant foot plates are rounder and do not exhibit the same degree of interdigital clefting as wild-type foot plates

digestive/alimentary system
• at E18 (~1 day prior to birth), homozygotes display fusion of the tongue with the unelevated palatal shelves, preventing proper formation of the oral cavity
• at E18 (~1 day prior to birth), all homozygotes display a bilateral cleft of the secondary palate
• palatal shelves fail to elevate and fuse in the dorsal midline

immune system
• at E18 (~1 day prior to birth), homozygotes display altered thymic morphology
• at E18, both the number and the size of developing medullary regions are reduced
• at E18, homozygotes display impaired differentiation of gamma-delta T lymphocyte lineage
• in contrast, differentiation of alpha-beta T cells is unaffected
• the total percentage of gamma-delta T cells, as well as those among the CD4-/CD8- double negative subset, is about one-half that observed in wild-type thymi

hearing/vestibular/ear
• at E18, homozygotes exhibit a significant increase in the total number and density of cochlear hair cells, primariliy due to an increase in IHCs (J:53432)
• a significant reduction in the ratio of OHCs to IHCs is observed (J:53432)
• at E18, homozygotes display multiple IHC duplications, resulting in the addition of a nearly complete second row of IHCs (J:53432)
• at E18, homozygotes often exhibit abnormal orientation of IHC stereociliary bundles
• at E18, patterning in OHC rows is much more irregular than in wild-type
• at E18, homozygotes contain four rather than three rows of OHCs in some regions of the sensory epithelium (J:53432)
• at E18, the overall pattern of non-sensory supporting cells is present; however, some regions appear to contain a reduced number of supporting cell nuclei
• some pairs of IHCs appear to be in contact with one another, suggesting absence of interdigitating supporting cells at these positions

nervous system
• at E18, homozygotes exhibit a significant increase in the total number and density of cochlear hair cells, primariliy due to an increase in IHCs (J:53432)
• a significant reduction in the ratio of OHCs to IHCs is observed (J:53432)
• at E18, homozygotes display multiple IHC duplications, resulting in the addition of a nearly complete second row of IHCs (J:53432)
• at E18, homozygotes contain four rather than three rows of OHCs in some regions of the sensory epithelium (J:53432)
• at E18, homozygotes often exhibit abnormal orientation of IHC stereociliary bundles
• at E18, patterning in OHC rows is much more irregular than in wild-type

hematopoietic system
• at E18 (~1 day prior to birth), homozygotes display altered thymic morphology
• at E18, both the number and the size of developing medullary regions are reduced
• at E18, homozygotes display impaired differentiation of gamma-delta T lymphocyte lineage
• in contrast, differentiation of alpha-beta T cells is unaffected
• the total percentage of gamma-delta T cells, as well as those among the CD4-/CD8- double negative subset, is about one-half that observed in wild-type thymi

skeleton
• 5 of 13 newborn homozygotes show primary chondrogenic or secondary osseous fusions of the distal phalanges, with the hindfeet more severely affected
• several newborns exhibit splitting of the terminal phalanx of digit 2 of the hindfeet

endocrine/exocrine glands
• at E18 (~1 day prior to birth), homozygotes display altered thymic morphology
• at E18, both the number and the size of developing medullary regions are reduced

growth/size/body
• at E18 (~1 day prior to birth), homozygotes display fusion of the tongue with the unelevated palatal shelves, preventing proper formation of the oral cavity
• at E18 (~1 day prior to birth), all homozygotes display a bilateral cleft of the secondary palate
• palatal shelves fail to elevate and fuse in the dorsal midline




Genotype
MGI:3691117
ht3
Allelic
Composition
Jag2tm1Grid/Jag2+
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• heterozygotes exhibit a slight but insignificant increase in average IHC density and total number relative to wild-type mice
• heterozygotes display a relatively high incidence of IHC duplications relative to wild-type mice

nervous system
• heterozygotes exhibit a slight but insignificant increase in average IHC density and total number relative to wild-type mice
• heterozygotes display a relatively high incidence of IHC duplications relative to wild-type mice




Genotype
MGI:3776435
cx4
Allelic
Composition
Dll1tm1Gos/Dll1tm2Gos
Jag2tm1Grid/Jag2tm1Grid
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Gos mutation (2 available); any Dll1 mutation (46 available)
Dll1tm2Gos mutation (0 available); any Dll1 mutation (46 available)
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• unlike in wild-type mice, cells within the organ of Corti continue to proliferate between E14.5 and E17.5
• hair cells are disorganized and very densely packed
• cochlea exhibit a greater increase in inner hair cells than in Jag2tm1Grid homozygotes
• hair cell stereocilia bundles exhibit a lose of polarity and disorganization
• many of the missing supporting cells are derived from the Deiter's cell population

nervous system
• hair cells are disorganized and very densely packed
• cochlea exhibit a greater increase in inner hair cells than in Jag2tm1Grid homozygotes
• hair cell stereocilia bundles exhibit a lose of polarity and disorganization




Genotype
MGI:3776431
cx5
Allelic
Composition
Dll1tm1Gos/Dll1+
Jag2tm1Grid/Jag2+
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Gos mutation (2 available); any Dll1 mutation (46 available)
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• cochlea possess increased inner hair cells but not as many as in Jag2tm1Grid homozygotes

nervous system
• cochlea possess increased inner hair cells but not as many as in Jag2tm1Grid homozygotes




Genotype
MGI:3776434
cx6
Allelic
Composition
Dll1tm1Gos/Dll1+
Jag2tm1Grid/Jag2tm1Grid
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Gos mutation (2 available); any Dll1 mutation (46 available)
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• cells within the organ of Corti, including pillar cells, Dieter's cells and Hensen's cells, continue to proliferate between E14.5 and E17.5 unlike in wild-type mice
• cochlea exhibit a greater increase in inner hair cells than in Jag2tm1Grid homozygotes

nervous system
• cochlea exhibit a greater increase in inner hair cells than in Jag2tm1Grid homozygotes




Genotype
MGI:3776430
cx7
Allelic
Composition
Dll1tm2Gos/Dll1+
Jag2tm1Grid/Jag2+
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm2Gos mutation (0 available); any Dll1 mutation (46 available)
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• cochlea possess increased inner hair cells but not as many as in Jag2tm1Grid homozygotes

nervous system
• cochlea possess increased inner hair cells but not as many as in Jag2tm1Grid homozygotes




Genotype
MGI:3696038
cx8
Allelic
Composition
Jag2tm1Grid/Jag2tm1Grid
Lfngtm1Grid/Lfng+
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
Lfngtm1Grid mutation (1 available); any Lfng mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• at E18, these mutants display only partial suppression of the Jag2tm1Grid homozygous mutant phenotype in the IHC row
• in these mice, regions of two rows of IHCs are interspersed with regions of a single row of IHCs

nervous system
• at E18, these mutants display only partial suppression of the Jag2tm1Grid homozygous mutant phenotype in the IHC row
• in these mice, regions of two rows of IHCs are interspersed with regions of a single row of IHCs




Genotype
MGI:3696037
cx9
Allelic
Composition
Jag2tm1Grid/Jag2tm1Grid
Lfngtm1Grid/Lfngtm1Grid
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
Lfngtm1Grid mutation (1 available); any Lfng mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• surprisingly, at E18, double homozygotes display total suppression of the increase in number of hair cells in the IHC row observed in single Jag2tm1Grid homozygotes; this effect is specific for IHCs
• at E18, double homozygotes display disrupted patterning of the OHC rows, similar to single Jag2tm1Grid homozygotes
• at E18, double homozygotes display generation of supernumerary OHCs, similar to single Jag2tm1Grid homozygotes

nervous system
• surprisingly, at E18, double homozygotes display total suppression of the increase in number of hair cells in the IHC row observed in single Jag2tm1Grid homozygotes; this effect is specific for IHCs
• at E18, double homozygotes display disrupted patterning of the OHC rows, similar to single Jag2tm1Grid homozygotes
• at E18, double homozygotes display generation of supernumerary OHCs, similar to single Jag2tm1Grid homozygotes





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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory