Phenotypes associated with this allele

• Allele Symbol: Brs3^tm1Jfb
• Allele Name: targeted mutation 1, James F Battey
• Allele ID: MGI:2657217
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brs3^tm1Jfb/Brs3^tm1Jfb	B6.129X1-Brs3^tm1Jfb	MGI:3785002

Genotype
MGI:3785002

hm1

• Allelic Composition: Brs3^tm1Jfb/Brs3^tm1Jfb
• Genetic Background: B6.129X1-Brs3^tm1Jfb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:134021 )

♀ • mutants fed ad lib show significantly greater body weights than wild-type mice fed ad lib starting at 13 weeks of age and continuing throughout the experiment duration; by 32 weeks, mutant animals displayed 28% greater body weight than controls

♀ • pair-feeding of mutant animals to match caloric intake of ad lib-fed wild-type normalized body weights of mutants so that pair-fed animal weights are similar to ad lib-fed wild-type mice

♀ • at 10 weeks of age, pair-fed mutants are significantly heavier than wild-type mice

adipose tissue

adipose tissue phenotype ( J:134021 )

♀N • increased weight at 10 weeks of age of pair-fed mutants does not correlate to increased brown adipose tissue compared to wild-type

increased brown adipose tissue amount ( J:134021 )

♀ • at 36 weeks of age, mutants have significantly more brown fat than wild-type mice

increased white adipose tissue amount ( J:134021 )

♀ • increased weight at 10 weeks of age of pair-fed mutants is accompanied by significant increases in subcutaneous and epididymal fat

♀ • at 36 weeks of age, mutants have significantly more subcutaneous and epididymal fat than wild-type mice

abnormal epididymal fat pad morphology ( J:134021 )

♀

homeostasis/metabolism

increased circulating insulin level ( J:134021 )

♀ • ad lib-fed mutants show significantly elevated insulin levels relative to ad lib fed wild-type mice

♀ • pair-fed mutants showed normalized insulin levels to levels in ad lib-fed wild-type mice

increased circulating leptin level ( J:134021 )

♀ • at 10 weeks of age, pair-fed mutants have elevated plasma leptin levels compared to wild-type animals

behavior/neurological

abnormal food intake ( J:134021 )

♀ • ad lib-fed mutants show a decrease in grams of food consumed as percentage of body weight compared to wild-type at 20 and 28 weeks of age; less food is consumed relative to body weight

increased food intake ( J:134021 )

♀ • over course of experiment, mutants fed ad lib show a higher food intake than ad lib-fed wild-type

♀ • number of food pellets consumed in 24 hours greater in ad lib-fed mutants; number of meals taken in 24 hours is not different from ad lib-fed wild-type mice but meal size is significantly greater