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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Iglc1tm2Ust
targeted mutation 2, Ursula Storb
MGI:2657246
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Iglc1tm2Ust/Iglc1tm2Ust involves: 129S7/SvEvBrd MGI:3719675
ht2
 		Iglc1tm2Ust/Iglc1+ involves: 129S7/SvEvBrd * C57BL/6J MGI:4818912
cx3
 		Igktm1Dhu/Igktm1Dhu
Iglc1tm2Ust/Iglc1tm2Ust 		involves: 129S7/SvEvBrd MGI:3719676
cx4
 		Igktm1Dhu/Igktm1Dhu
Iglc1tm2Ust/Iglc1tm2Ust 		involves: 129S7/SvEvBrd * C57BL/6J MGI:2657249
cx5
 		Iglc1tm2Ust/Iglc1tm2Ust
Ptpn6me-v/Ptpn6me-v 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3719674


Genotype
MGI:3719675
hm1
Allelic
Composition		 Iglc1tm2Ust/Iglc1tm2Ust
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iglc1tm2Ust mutation (0 available); any Iglc1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:113218 )
• lambda1-val B cell numbers are reduced 4-fold compared to in wild-type mice
• the total number of B cells is reduced relative to wild-type
• lambda2, 3 B cells are decreased relative to wild-type mice

immune system
decreased B cell number ( J:113218 )
• lambda1-val B cell numbers are reduced 4-fold compared to in wild-type mice
• the total number of B cells is reduced relative to wild-type
• lambda2, 3 B cells are decreased relative to wild-type mice




Genotype
MGI:4818912
ht2
Allelic
Composition		 Iglc1tm2Ust/Iglc1+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iglc1tm2Ust mutation (0 available); any Iglc1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immunoglobulin light chain V-J recombination ( J:74717 )
• VJ lamda 1 rearrangement is enhanced, however most of the rearrangements are nonproductive
• frequency of productive lamda 1 rearrangements is reduced about 10-fold

immune system
abnormal immunoglobulin light chain V-J recombination ( J:74717 )
• VJ lamda 1 rearrangement is enhanced, however most of the rearrangements are nonproductive
• frequency of productive lamda 1 rearrangements is reduced about 10-fold




Genotype
MGI:3719676
cx3
Allelic
Composition		 Igktm1Dhu/Igktm1Dhu
Iglc1tm2Ust/Iglc1tm2Ust
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igktm1Dhu mutation (1 available); any Igk mutation (26 available)
Iglc1tm2Ust mutation (0 available); any Iglc1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B-1a cell number ( J:113218 )
• B-1a B cell numbers are increased relative to in Igktm1Dhu homozygotes and 4- to 8-fold higher and 3.5 times more in the spleen and peritoneal cavity, respectively, relative to Igktm1Dhu Igl-C1tm1Ust homozygotes
• B-1a B cells comprise 50% of peritoneal lymphocytes compared to only 14.5% in Igktm1Dhu homozygotes and 18.5% in Igktm1Dhu Igl-C1tm1Ust homozygotes
• the ratio of B1 to B2 cells is increased relative to Igktm1Dhu homozygotes

hematopoietic system
increased B-1a cell number ( J:113218 )
• B-1a B cell numbers are increased relative to in Igktm1Dhu homozygotes and 4- to 8-fold higher and 3.5 times more in the spleen and peritoneal cavity, respectively, relative to Igktm1Dhu Igl-C1tm1Ust homozygotes
• B-1a B cells comprise 50% of peritoneal lymphocytes compared to only 14.5% in Igktm1Dhu homozygotes and 18.5% in Igktm1Dhu Igl-C1tm1Ust homozygotes
• the ratio of B1 to B2 cells is increased relative to Igktm1Dhu homozygotes




Genotype
MGI:2657249
cx4
Allelic
Composition		 Igktm1Dhu/Igktm1Dhu
Iglc1tm2Ust/Iglc1tm2Ust
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igktm1Dhu mutation (1 available); any Igk mutation (26 available)
Iglc1tm2Ust mutation (0 available); any Iglc1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:74717 )
• generation of immature lamda1 B cells in the bone marrow and their continued maturation to mature B cells in the spleen are defective
decreased immature B cell number ( J:74717 )
• number of immature lamda 1 B cells is decreased 2- to 3-fold in the bone marrow
decreased transitional stage T1 B cell number ( J:74717 )
• 3-fold decrease in lamda 1 transitional type 1 (T1) B cells
decreased transitional stage T2 B cell number ( J:74717 )
• 10-fold decrease in the number of transitional 2 (T2) lamda 1 B cells
decreased B cell number ( J:74717 )
• reduced numbers of immature lambda 1 B cells in bone marrow and reduced numbers of mature lambda 1 B cells in spleen
decreased mature B cell number ( J:74717 )
• 6-fold decrease in the number of mature lamda 1 B cells
• number of recirculating mature lamda 1 B cells in the bone marrow is decreased 7- to 20-fold
decreased marginal zone B cell number ( J:74717 )
• decrease in marginal zone lamda 1 B cells

hematopoietic system
abnormal B cell differentiation ( J:74717 )
• generation of immature lamda1 B cells in the bone marrow and their continued maturation to mature B cells in the spleen are defective
decreased immature B cell number ( J:74717 )
• number of immature lamda 1 B cells is decreased 2- to 3-fold in the bone marrow
decreased transitional stage T1 B cell number ( J:74717 )
• 3-fold decrease in lamda 1 transitional type 1 (T1) B cells
decreased transitional stage T2 B cell number ( J:74717 )
• 10-fold decrease in the number of transitional 2 (T2) lamda 1 B cells
decreased B cell number ( J:74717 )
• reduced numbers of immature lambda 1 B cells in bone marrow and reduced numbers of mature lambda 1 B cells in spleen
decreased mature B cell number ( J:74717 )
• 6-fold decrease in the number of mature lamda 1 B cells
• number of recirculating mature lamda 1 B cells in the bone marrow is decreased 7- to 20-fold
decreased marginal zone B cell number ( J:74717 )
• decrease in marginal zone lamda 1 B cells




Genotype
MGI:3719674
cx5
Allelic
Composition		 Iglc1tm2Ust/Iglc1tm2Ust
Ptpn6me-v/Ptpn6me-v
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iglc1tm2Ust mutation (0 available); any Iglc1 mutation (4 available)
Ptpn6me-v mutation (3 available); any Ptpn6 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:113218 )
• lambda1-val B cell numbers are reduced 14-fold compared to in wild-type mice
• the total number of B cells is reduced relative to wild-type
• lambda2, 3 B cells are decreased relative to wild-type mice to a greater extent than in a Ptpn6+ background

hematopoietic system
decreased B cell number ( J:113218 )
• lambda1-val B cell numbers are reduced 14-fold compared to in wild-type mice
• the total number of B cells is reduced relative to wild-type
• lambda2, 3 B cells are decreased relative to wild-type mice to a greater extent than in a Ptpn6+ background




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory