Phenotypes associated with this allele

• Allele Symbol: Atrn^mg-6J
• Allele Name: mahogany 6 Jackson
• Allele ID: MGI:2657306
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atrn^mg-6J/Atrn^mg-6J	CAST/Ei-Atrn^mg-6J	MGI:3575831
hm2	Atrn^mg-6J/Atrn^mg-6J	involves: C3H/HeSnJ * CAST/Ei	MGI:3575833

Genotype
MGI:3575831

hm1

• Allelic Composition: Atrn^mg-6J/Atrn^mg-6J
• Genetic Background: CAST/Ei-Atrn^mg-6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:96070 )

• most died in the third or fourth week of life

pigmentation

darkened coat color ( J:96070 )

• mahogany coat

behavior/neurological

tremors ( J:96070 )

• severe tremors

abnormal gait ( J:96070 )

• sprawling gait

nervous system

abnormal neuron morphology ( J:96070 )

• axons, dendrites, and neuronal soma contained vacuoles

integument

darkened coat color ( J:96070 )

• mahogany coat

Genotype
MGI:3575833

hm2

• Allelic Composition: Atrn^mg-6J/Atrn^mg-6J
• Genetic Background: involves: C3H/HeSnJ * CAST/Ei

pigmentation

darkened coat color ( J:96070 )

• mahogany coat

behavior/neurological

tremors ( J:96070 )

• less severe tremors than on the CAST/Ei background

nervous system

abnormal brain morphology ( J:96070 )

abnormal brain white matter morphology ( J:96070 )

• white matter of brain showed pale staining when stained for myelin compared to controls

abnormal medulla oblongata morphology ( J:96070 )

• vacuoles began to appear in various nuclei in medulla at 2 months of age

abnormal thalamus morphology ( J:96070 )

• vacuoles began to appear in the thalamus at 2 months of age

abnormal cerebral cortex morphology ( J:96070 )

• vacuoles appeared in layers 3 and 4 of the cerebral cortex beginning at 2 months of age

abnormal cerebellum morphology ( J:96070 )

• vacuoles appeared in the cerebellar granule cell layer beginning at 2 months of age

brain vacuoles ( J:96070 )

• observed vacuoles in the brain of mutants with vacuolization becoming more severe and widespread with age and by 9 months of age, vacuoles were seen everywhere in the brain

abnormal spinal cord white matter morphology ( J:96070 )

• white matter spinal cord showed pale staining when stained for myelin compared to controls

integument

darkened coat color ( J:96070 )

• mahogany coat