All Phenotypes H2<dlAb1-Ea> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

H2^dlAb1-Ea
targeted deletion, H2 complex
MGI:2658725

Summary

13 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2^dlAb1-Ea/H2^dlAb1-Ea	B6.129S2-H2^dlAb1-Ea/J	MGI:3580480
hm2	H2^dlAb1-Ea/H2^dlAb1-Ea	involves: 129S2/SvPas * C57BL/6	MGI:4436873
cx3	H2^dlAb1-Ea/H2^dlAb1-Ea Marchf1^tm1.1Sish/Marchf1^tm1.1Sish	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:4436870
cx4	H2^dlAb1-Ea/H2^dlAb1-Ea Rag1^tm1Mom/Rag1^tm1Mom Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	MGI:5635499
cx5	H2^dlAb1-Ea/H2^dlAb1-Ea Rag1^tm1Mom/Rag1^tm1Mom Tg(HLA-DRA,HLA-DRB5*0101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	MGI:5635503
cx6	H2^dlAb1-Ea/H2^dlAb1-Ea Rr381^em2Kap/Rr381^em2Kap	involves: 129S2/SvPas * C57BL/6	MGI:7439200
cx7	H2^dlAb1-Ea/H2^dlAb1-Ea Rr381^em4Kap/Rr381^em4Kap	involves: 129S2/SvPas * C57BL/6	MGI:7439204
cx8	H2^dlAb1-Ea/H2^dlAb1-Ea Rr381^em5Kap/Rr381^em5Kap	involves: 129S2/SvPas * C57BL/6	MGI:7439206
cx9	H2^dlAb1-Ea/H2^dlAb1-Ea Psmb11^{tm1(Psmb8)Khog}/Psmb11^{tm1(Psmb8)Khog}	involves: 129S2/SvPas * C57BL/6	MGI:5514414
cx10	H2^dlAb1-Ea/H2^dlAb1-Ea Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0	involves: 129S2/SvPas * C57BL/6	MGI:5635484
cx11	H2^dlAb1-Ea/H2^dlAb1-Ea Tg(TRATL3A6,TRBTL3A6)#Kito/0	involves: 129S2/SvPas * C57BL/6	MGI:5635486
cx12	H2^dlAb1-Ea/H2^dlAb1-Ea Tg(HLA-DRA,HLA-DRB5*0101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0	involves: 129S2/SvPas * C57BL/6	MGI:5635488
cx13	H2^dlAb1-Ea/H2^dlAb1-Ea Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0	involves: 129S2/SvPas * C57BL/6	MGI:5635492

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea
Genetic Background	B6.129S2-H2^dlAb1-Ea/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:123934 )

• following infection with either a low or high dose of IOE, mice succumb to the infection at 11 to 15 days and 7 to 9 days, respectively, compared to wild-type mice, which succumb at 14 to 17 days and 8 to 12 days, respectively

immune system

increased susceptibility to bacterial infection ( J:123934 )

• mice are more susceptible to infection with a monocytotropic Ehrlichia bacteria from Ixodes ovatrus ticks (IOE) than wild-type mice

• mice have higher burdens of Ehrlichia bacteria in all organs following infection than do wild-type mice

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:157516 )

N	• stimulated dendritic cells produce normal amounts of IL-12 and TNF-alpha

abnormal T cell number ( J:57484 )

decreased CD4-positive, alpha-beta T cell number ( J:57484 )

• significantly decreased number of CD4+ thymocytes

• almost completely absent in spleen and lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:57484 )

abnormal immunoglobulin level ( J:57484 )

decreased IgG1 level ( J:57484 )

decreased IgG2a level ( J:57484 )

increased IgM level ( J:57484 )

hematopoietic system

abnormal T cell number ( J:57484 )

decreased CD4-positive, alpha-beta T cell number ( J:57484 )

• significantly decreased number of CD4+ thymocytes

• almost completely absent in spleen and lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:57484 )

abnormal immunoglobulin level ( J:57484 )

decreased IgG1 level ( J:57484 )

decreased IgG2a level ( J:57484 )

increased IgM level ( J:57484 )

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Marchf1^tm1.1Sish/Marchf1^tm1.1Sish
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)
Marchf1^tm1.1Sish mutation (1 available); any Marchf1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:157516 )

N	• stimulated dendritic cells produce normal amounts of IL-12 and TNF-alpha

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Rag1^tm1Mom/Rag1^tm1Mom Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)
Rag1^tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(HLA-DRA,HLA-DRB5*0101)hiKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

brain inflammation ( J:189816 )

• mice develop spontaneous autoimmune encephalitis with an incidence of 58.3; onset of disease is around 6 weeks of age

nervous system

brain inflammation ( J:189816 )

• mice develop spontaneous autoimmune encephalitis with an incidence of 58.3; onset of disease is around 6 weeks of age

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Rag1^tm1Mom/Rag1^tm1Mom Tg(HLA-DRA,HLA-DRB5*0101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)
Rag1^tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(HLA-DRA,HLA-DRB5*0101)loKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

brain inflammation ( J:189816 )

• mice develop spontaneous experimental autoimmune encephalitis with an incidence of 5%; onset of disease is around 12 weeks of age

nervous system

brain inflammation ( J:189816 )

• mice develop spontaneous experimental autoimmune encephalitis with an incidence of 5%; onset of disease is around 12 weeks of age

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Rr381^em2Kap/Rr381^em2Kap
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)
Rr381^em2Kap mutation (0 available); any Rr381 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

absent CD4-positive, alpha-beta T cells ( J:333471 )

immune system

absent CD4-positive, alpha-beta T cells ( J:333471 )

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Rr381^em4Kap/Rr381^em4Kap
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)
Rr381^em4Kap mutation (0 available); any Rr381 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

absent CD8-positive, alpha-beta T cells ( J:333471 )

• almost complete redirection of MHC class I-specific T cells to CD4+ lineage

immune system

absent CD8-positive, alpha-beta T cells ( J:333471 )

• almost complete redirection of MHC class I-specific T cells to CD4+ lineage

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Rr381^em5Kap/Rr381^em5Kap
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)
Rr381^em5Kap mutation (0 available); any Rr381 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

absent CD8-positive, alpha-beta T cells ( J:333471 )

• almost complete redirection of MHC class I-specific T cells to CD4+ lineage

immune system

absent CD8-positive, alpha-beta T cells ( J:333471 )

• almost complete redirection of MHC class I-specific T cells to CD4+ lineage

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Psmb11^{tm1(Psmb8)Khog}/Psmb11^{tm1(Psmb8)Khog}
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)
Psmb11^{tm1(Psmb8)Khog} mutation (0 available); any Psmb11 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:196156 )

• perturbed selection at the double positive or cortical stage of CD8 T cell development

decreased CD8-positive, alpha-beta T cell number ( J:196156 )

• immature and mater thymocytes

hematopoietic system

abnormal T cell differentiation ( J:196156 )

• perturbed selection at the double positive or cortical stage of CD8 T cell development

decreased CD8-positive, alpha-beta T cell number ( J:196156 )

• immature and mater thymocytes

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)
Tg(HLA-DRA,HLA-DRB5*0101)hiKito mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:189816 )

N	• mice do not develop experimental autoimmune encephalitis following induction with MBP (83-99)

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:189816 )

N	• mice do not develop experimental autoimmune encephalitis following induction with MBP (83-99)

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Tg(HLA-DRA,HLA-DRB5*0101)loKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)
Tg(HLA-DRA,HLA-DRB5*0101)loKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:189816 )

• mice rarely exhibit experimental autoimmune encephalitis when immunized with CFA or pertussis alone, but immunization with MBP (83-99) in CFA with pertussis elicits encephalitis in 47% of mice

brain inflammation ( J:189816 )

• mice develop spontaneous autoimmune encephalitis with an incidence of <1%; onset of disease is around 21 weeks of age

nervous system

brain inflammation ( J:189816 )

• mice develop spontaneous autoimmune encephalitis with an incidence of <1%; onset of disease is around 21 weeks of age

Allelic Composition	H2^dlAb1-Ea/H2^dlAb1-Ea Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0 Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^dlAb1-Ea mutation (13 available); any H2 mutation (282 available)
Tg(HLA-DRA,HLA-DRB5*0101)hiKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased CD4-positive, alpha-beta T cell number ( J:189816 )

• mice show greater numbers of Th1-, Th17-, and GM-CSF⁺-expressing CD4 T cells in response to MBP (83-99)

• mice that spontaneously develop EAE have greater numbers of MBP-specific Th1, and GM-CDF+ CD4+ T cells in the CNS during the course of spontaneous EAE

increased T-helper 1 cell number ( J:189816 )

• in both induced and spontaneous EAE mice

increased T-helper 17 cell number ( J:189816 )

• in both induced and spontaneous EAE mice

abnormal cytokine secretion ( J:189816 )

• mice show an increased production of IFN-gamma, IL-17, and GM-CSF cytokines in response to MBP (83-99)

• mice that spontaneously develop EAE exhibit an increased production of IFN-gamma, IL-7 and GM-CSF cytokines in the CNS

increased interferon-gamma secretion ( J:189816 )

• in both induced and spontaneous EAE mice

increased interleukin-17 secretion ( J:189816 )

• in both induced and spontaneous EAE mice

increased susceptibility to experimental autoimmune encephalomyelitis ( J:189816 )

• mice rarely exhibit experimental autoimmune encephalitis (EAE) when immunized with CFA or pertussis alone, but immunization with MBP (83-99) in CFA with pertussis elicits encephalitis in 90% of mice

increased inflammatory response ( J:189816 )

• mice that develop either induced or spontaneous EAE show mild redicultis of the spinal nerve root and mild neuritis of the cranial nerve root in less than 50% of sections examined

CNS inflammation ( J:189816 )

• mice that develop either induced or spontaneous EAE show severe/moderate inflammation in the spinal cord (meningomyelitis), with lesser involvement of the brainstem and infiltrates contain predominantly CD4+ T cells and mononuclear cells, as well as polymorphnuclear leukocytes/granulocytes

brain inflammation ( J:189816 )

• mice develop spontaneous experimental autoimmune encephalitis (EAE) with an incidence of 4.5%; onset of disease is around 10 weeks of age

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:189816 )

• both induced and spontaneous EAE mice develop ascending motor deficits

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:189816 )

• mice show greater numbers of Th1-, Th17-, and GM-CSF⁺-expressing CD4 T cells in response to MBP (83-99)

• mice that spontaneously develop EAE have greater numbers of MBP-specific Th1, and GM-CDF+ CD4+ T cells in the CNS during the course of spontaneous EAE

increased T-helper 1 cell number ( J:189816 )

• in both induced and spontaneous EAE mice

increased T-helper 17 cell number ( J:189816 )

• in both induced and spontaneous EAE mice

nervous system

CNS inflammation ( J:189816 )

brain inflammation ( J:189816 )

• mice develop spontaneous experimental autoimmune encephalitis (EAE) with an incidence of 4.5%; onset of disease is around 10 weeks of age

abnormal axon morphology ( J:189816 )

• both induced and spontaneous EAE mice exhibit swollen axons throughout the spinal cord

neuron degeneration ( J:189816 )

• both induced and spontaneous EAE mice exhibit degenerating neurons throughout the spinal cord

axon degeneration ( J:189816 )

• both induced and spontaneous EAE mice exhibit loss of axons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:189816

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