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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tial1tm1Mst
targeted mutation 1, Michel Streuli
MGI:2660803
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tial1tm1Mst/Tial1tm1Mst involves: 129S2/SvPas * C57BL/6 MGI:2660806
hm2
 		Tial1tm1Mst/Tial1tm1Mst involves: BALB/c MGI:3037313
hm3
 		Tial1tm1Mst/Tial1tm1Mst involves: BALB/c * C57BL/6 MGI:3037314


Genotype
MGI:2660806
hm1
Allelic
Composition		 Tial1tm1Mst/Tial1tm1Mst
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tial1tm1Mst mutation (0 available); any Tial1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Lack of germ cells in Tial1tm1Mst/Tial1tm1Mst mouse testes and ovaries

mortality/aging
postnatal lethality, incomplete penetrance ( J:46239 )
• less than half of the birthed pups survived to adulthood
prenatal lethality, incomplete penetrance ( J:46239 )
• greater than 60% died in utero

embryo

endocrine/exocrine glands
ovary hyperplasia ( J:46239 )
• hyperplastic sex cord derivatives resulted in ovaries that were 5 times larger by 8 months of age
small ovary ( J:46239 )
• prior to hyperplasia, the ovaries were smaller than those of wild-type
small testis ( J:46239 )
• approximately 1/3 the size of wild-type

growth/size/body
decreased embryo size ( J:46239 )
ovary hyperplasia ( J:46239 )
• hyperplastic sex cord derivatives resulted in ovaries that were 5 times larger by 8 months of age
postnatal growth retardation ( J:46239 )

reproductive system
decreased primordial germ cell number ( J:46239 )
• reduced number of primordial germ cells at the genital ridge at E11.5 and E13.5, putatively due to apoptosis
• no ectopic PGCs were observed
• germ cells were absent from the seminferous tubules
ovary hyperplasia ( J:46239 )
• hyperplastic sex cord derivatives resulted in ovaries that were 5 times larger by 8 months of age
small ovary ( J:46239 )
• prior to hyperplasia, the ovaries were smaller than those of wild-type
small testis ( J:46239 )
• approximately 1/3 the size of wild-type

cellular
decreased primordial germ cell number ( J:46239 )
• reduced number of primordial germ cells at the genital ridge at E11.5 and E13.5, putatively due to apoptosis
• no ectopic PGCs were observed
• germ cells were absent from the seminferous tubules




Genotype
MGI:3037313
hm2
Allelic
Composition		 Tial1tm1Mst/Tial1tm1Mst
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tial1tm1Mst mutation (0 available); any Tial1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:88770 )
• on a BALB/c background homozygotes die in utero




Genotype
MGI:3037314
hm3
Allelic
Composition		 Tial1tm1Mst/Tial1tm1Mst
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tial1tm1Mst mutation (0 available); any Tial1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:88770 )
• on a mixed BALB/c and C57BL/6 background ~10% of homozygotes survive




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory