About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tial1tm1Mst
targeted mutation 1, Michel Streuli
MGI:2660803
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tial1tm1Mst/Tial1tm1Mst involves: 129S2/SvPas * C57BL/6 MGI:2660806
hm2
Tial1tm1Mst/Tial1tm1Mst involves: BALB/c MGI:3037313
hm3
Tial1tm1Mst/Tial1tm1Mst involves: BALB/c * C57BL/6 MGI:3037314


Genotype
MGI:2660806
hm1
Allelic
Composition
Tial1tm1Mst/Tial1tm1Mst
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tial1tm1Mst mutation (0 available); any Tial1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lack of germ cells in Tial1tm1Mst/Tial1tm1Mst mouse testes and ovaries

mortality/aging
• less than half of the birthed pups survived to adulthood
• greater than 60% died in utero

embryo

endocrine/exocrine glands
• hyperplastic sex cord derivatives resulted in ovaries that were 5 times larger by 8 months of age
• prior to hyperplasia, the ovaries were smaller than those of wild-type
• approximately 1/3 the size of wild-type

growth/size/body
• hyperplastic sex cord derivatives resulted in ovaries that were 5 times larger by 8 months of age

reproductive system
• reduced number of primordial germ cells at the genital ridge at E11.5 and E13.5, putatively due to apoptosis
• no ectopic PGCs were observed
• germ cells were absent from the seminferous tubules
• hyperplastic sex cord derivatives resulted in ovaries that were 5 times larger by 8 months of age
• prior to hyperplasia, the ovaries were smaller than those of wild-type
• approximately 1/3 the size of wild-type

cellular
• germ cells were absent from the seminferous tubules
• reduced number of primordial germ cells at the genital ridge at E11.5 and E13.5, putatively due to apoptosis
• no ectopic PGCs were observed




Genotype
MGI:3037313
hm2
Allelic
Composition
Tial1tm1Mst/Tial1tm1Mst
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tial1tm1Mst mutation (0 available); any Tial1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• on a BALB/c background homozygotes die in utero




Genotype
MGI:3037314
hm3
Allelic
Composition
Tial1tm1Mst/Tial1tm1Mst
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tial1tm1Mst mutation (0 available); any Tial1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• on a mixed BALB/c and C57BL/6 background ~10% of homozygotes survive





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory