All Phenotypes Lyst<bg-slt> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lyst^bg-slt/Lyst^bg-slt	YZ57/Ch	MGI:2661024
cx2	Ednrb^s/Ednrb^s Lyst^bg-slt/Lyst^bg-slt	involves: C57BL/10Ch * Y257/Ch	MGI:2661415
cx3	Lyst^bg-slt/Lyst^bg-slt Myo5a^d/Myo5a^d	involves: CT/Ch * YZ57/Ch	MGI:2661034
cx4	Lyst^bg-slt/Lyst^bg-slt Oca2^p/Oca2^p	involves: CT/Ch * YZ57/Ch	MGI:2661158
cx5	Lyst^bg-slt/Lyst^bg-slt Myo5a^d/Myo5a^d Oca2^p/Oca2^p Tyrp1^b/Tyrp1^b	involves: CT/Ch * YZ57/Ch	MGI:2661267
cx6	Hps6^ru/Hps6^ru Lyst^bg-slt/Lyst^bg-slt	involves: YZ57/Ch	MGI:2661072

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:25388 )

• medullary pigment was highly clumped, though individual granules could be resolved in some medullary septae

• some granules were long ovals, but irregular shapes were common

• cortical granule shape varied from oval to nearly spherical

abnormal choroid pigmentation ( J:25388 )

• melanocyte pigment granules in the choroid were few in number, and were unusually large

abnormal ciliary body pigmentation ( J:25388 )

• melanocyte pigment granules in the choroid were few in number, and were unusually large

abnormal iris pigmentation ( J:25388 )

• melanocyte pigment granules in the iris were few in number, and were unusually large

abnormal retina pigmentation ( J:25388 )

• melanocyte pigment granules in the retina were few in number, and were unusually large

vision/eye

abnormal choroid pigmentation ( J:25388 )

• melanocyte pigment granules in the choroid were few in number, and were unusually large

abnormal ciliary body pigmentation ( J:25388 )

• melanocyte pigment granules in the choroid were few in number, and were unusually large

abnormal iris pigmentation ( J:25388 )

• melanocyte pigment granules in the iris were few in number, and were unusually large

abnormal retina pigmentation ( J:25388 )

• melanocyte pigment granules in the retina were few in number, and were unusually large

integument

diluted coat color ( J:25388 )

• medullary pigment was highly clumped, though individual granules could be resolved in some medullary septae

• some granules were long ovals, but irregular shapes were common

• cortical granule shape varied from oval to nearly spherical

premature hair loss ( J:83269 )

• about 5% of mice lost most of the dorsum hairs of the first coat prematurely following cessation of the first hair growth cycle

delayed hair regrowth ( J:83269 )

• about 5% of mice lost most of the dorsum hairs of the first coat prematurely following cessation of the first hair growth cycle

• an apparently normal second coat grew in these mice but the second hair growth cycle appeared somewhat delayed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Chediak-Higashi syndrome		DOID:2935	OMIM:214500	J:25388

Allelic Composition	Ednrb^s/Ednrb^s Lyst^bg-slt/Lyst^bg-slt
Genetic Background	involves: C57BL/10Ch * Y257/Ch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s mutation (19 available); any Ednrb mutation (104 available)
Lyst^bg-slt mutation (0 available); any Lyst mutation (225 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal eye pigmentation ( J:25388 )

• eye color was ruby-red

vision/eye

abnormal eye pigmentation ( J:25388 )

• eye color was ruby-red

Allelic Composition	Lyst^bg-slt/Lyst^bg-slt Myo5a^d/Myo5a^d
Genetic Background	involves: CT/Ch * YZ57/Ch

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:25388 )

• coat appeared silvery blue

• melanin pigments were nearly absent from the distal third of the hair shaft, but populate the more proximal regions as heavily as in homozygous slate mice

vision/eye

vision/eye phenotype ( J:25388 )

N	• eye color was black, except animals that were piebald had reddish eyes

integument

diluted coat color ( J:25388 )

• coat appeared silvery blue

• melanin pigments were nearly absent from the distal third of the hair shaft, but populate the more proximal regions as heavily as in homozygous slate mice

Allelic Composition	Lyst^bg-slt/Lyst^bg-slt Oca2^p/Oca2^p
Genetic Background	involves: CT/Ch * YZ57/Ch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyst^bg-slt mutation (0 available); any Lyst mutation (225 available)
Oca2^p mutation (11 available); any Oca2 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:25388 )

• coat was slightly lighter than those of mice homozygous for p alone

• cortical pigment was absent

• the few medullary septae that lacked pigment were in the distal hair shaf

• granules resembled those of mice homozygous for p alone except a few were larger

abnormal eye pigmentation ( J:25388 )

• eye color was pink

vision/eye

abnormal eye pigmentation ( J:25388 )

• eye color was pink

integument

diluted coat color ( J:25388 )

• coat was slightly lighter than those of mice homozygous for p alone

• cortical pigment was absent

• the few medullary septae that lacked pigment were in the distal hair shaf

• granules resembled those of mice homozygous for p alone except a few were larger

Allelic Composition	Lyst^bg-slt/Lyst^bg-slt Myo5a^d/Myo5a^d Oca2^p/Oca2^p Tyrp1^b/Tyrp1^b
Genetic Background	involves: CT/Ch * YZ57/Ch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyst^bg-slt mutation (0 available); any Lyst mutation (225 available)
Myo5a^d mutation (105 available); any Myo5a mutation (265 available)
Oca2^p mutation (11 available); any Oca2 mutation (70 available)
Tyrp1^b mutation (29 available); any Tyrp1 mutation (162 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:83269 )

integument

diluted coat color ( J:83269 )

premature hair loss ( J:83269 )

• random thinning of the coat appeared during the third week of age

abnormal hair cycle ( J:83269 )

delayed hair regrowth ( J:83269 )

• coat thinning at three weeks of age was followed by a short lag in the second hair growth cycle

Allelic Composition	Hps6^ru/Hps6^ru Lyst^bg-slt/Lyst^bg-slt
Genetic Background	involves: YZ57/Ch

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hps6^ru mutation (3 available); any Hps6 mutation (28 available)
Lyst^bg-slt mutation (0 available); any Lyst mutation (225 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:25388 )

• coat color was off-white

• cortical pigment was absent

• medullary pigment granules were extremely reduced or absent, with more in proximal regions of the hair shaft than in distal portions

• many granules were clumped and irregular in shape

decreased eye pigmentation ( J:25388 )

• eye color was pink

vision/eye

decreased eye pigmentation ( J:25388 )

• eye color was pink

integument

diluted coat color ( J:25388 )

• coat color was off-white

• cortical pigment was absent

• medullary pigment granules were extremely reduced or absent, with more in proximal regions of the hair shaft than in distal portions

• many granules were clumped and irregular in shape

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