Phenotypes associated with this allele

• Allele Symbol: Slc15a2^tm1Dan
• Allele Name: targeted mutation 1, Hannelore Daniel
• Allele ID: MGI:2661036
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc15a2^tm1Dan/Slc15a2^tm1Dan	involves: 129 * C57BL/6	MGI:2661037

Genotype
MGI:2661037

hm1

• Allelic Composition: Slc15a2^tm1Dan/Slc15a2^tm1Dan
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:83166 )

N • homozygotes show normal urinary excretion of amino acids, total protein, and creatinine relative to control littermates

N • although homozygotes display a clear tendency towards an increased amino acid-to-creatinine ratio for most free amino acids analyzed (e.g. glycine and leucine excretion rates are increased by 35% and 31%, respectively), only the ratio for leucine reaches the level of significance in male homozygotes, indicating that renal excretion of amino acids and amino acid nitrogen is only modestly affected

abnormal renal reabsorption ( J:83166 )

• after in vivo administration of tracer dipeptides (i.e. the fluorophore-conjugated dipeptide d-Ala-Lys-AMCA and the radiolabeled dipeptide d-[3H]Phe-Ala), homozygotes show a severe reduction in the accumulation of hydrolysis-resistant dipeptides in the kidney, indicating impaired tubule reabsorption of peptide-bound amino acids

abnormal renal protein reabsorption ( J:83166 )

• homozygotes display impaired tubular reabsorption of peptide-bound amino acids in the kidney

homeostasis/metabolism

abnormal renal protein reabsorption ( J:83166 )

• homozygotes display impaired tubular reabsorption of peptide-bound amino acids in the kidney