About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itgaltm1Bll
targeted mutation 1, Christie M Ballantyne
MGI:2661083
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itgaltm1Bll/Itgaltm1Bll B6.129S7-Itgaltm1Bll MGI:3583098
hm2
 		Itgaltm1Bll/Itgaltm1Bll B6.129S7-Itgaltm1Bll/J MGI:3785285
hm3
 		Itgaltm1Bll/Itgaltm1Bll involves: 129S7/SvEvBrd MGI:3817277
hm4
 		Itgaltm1Bll/Itgaltm1Bll involves: 129S7/SvEvBrd * C57BL/6J MGI:2661084
ht5
 		Itgaltm1Bll/Itgal+ involves: 129S7/SvEvBrd MGI:6367662
cx6
 		Edil3tm1Tq/Edil3tm1Tq
Itgaltm1Bll/Itgaltm1Bll 		involves: 129 * C57BL/6 MGI:3817278


Genotype
MGI:3583098
hm1
Allelic
Composition		 Itgaltm1Bll/Itgaltm1Bll
Genetic
Background		 B6.129S7-Itgaltm1Bll
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Bll mutation (2 available); any Itgal mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte adhesion ( J:100242 )
• leukocyte adhesion efficiency in inflamed vessels is significantly reduced compared to wildtype, homozygous Icam1tm1Alb, and homozygous Itgamtm1Bll mice
• 32% of leukocytes adhere to endothelium compared to 95% in wildtype, with adherence decreasing to 5% in the presence of Icam1 antibodies
abnormal leukocyte tethering or rolling ( J:100242 )
• treatment with Icam1 antibodies increases leukocyte rolling velocity after TNF-alpha stimulation in venules
decreased T cell proliferation ( J:90954 )
• reduced staphylococcal enterotoxin A (SEA)-induced T cell proliferation in splenocytes
increased leukocyte cell number ( J:100242 )
• total leukocyte numbers, polymophonuclear cell numbers and mononuclear cell numbers are increased
increased neutrophil cell number ( J:100242 )
• 4-fold increase in the number of circulating neutrophils
impaired natural killer cell mediated cytotoxicity ( J:90954 )
• NK cell cytotoxicity was reduced

hematopoietic system
abnormal leukocyte adhesion ( J:100242 )
• leukocyte adhesion efficiency in inflamed vessels is significantly reduced compared to wildtype, homozygous Icam1tm1Alb, and homozygous Itgamtm1Bll mice
• 32% of leukocytes adhere to endothelium compared to 95% in wildtype, with adherence decreasing to 5% in the presence of Icam1 antibodies
abnormal leukocyte tethering or rolling ( J:100242 )
• treatment with Icam1 antibodies increases leukocyte rolling velocity after TNF-alpha stimulation in venules
decreased T cell proliferation ( J:90954 )
• reduced staphylococcal enterotoxin A (SEA)-induced T cell proliferation in splenocytes
increased leukocyte cell number ( J:100242 )
• total leukocyte numbers, polymophonuclear cell numbers and mononuclear cell numbers are increased
increased neutrophil cell number ( J:100242 )
• 4-fold increase in the number of circulating neutrophils
impaired natural killer cell mediated cytotoxicity ( J:90954 )
• NK cell cytotoxicity was reduced

cellular
abnormal leukocyte adhesion ( J:100242 )
• leukocyte adhesion efficiency in inflamed vessels is significantly reduced compared to wildtype, homozygous Icam1tm1Alb, and homozygous Itgamtm1Bll mice
• 32% of leukocytes adhere to endothelium compared to 95% in wildtype, with adherence decreasing to 5% in the presence of Icam1 antibodies
abnormal leukocyte tethering or rolling ( J:100242 )
• treatment with Icam1 antibodies increases leukocyte rolling velocity after TNF-alpha stimulation in venules
decreased T cell proliferation ( J:90954 )
• reduced staphylococcal enterotoxin A (SEA)-induced T cell proliferation in splenocytes




Genotype
MGI:3785285
hm2
Allelic
Composition		 Itgaltm1Bll/Itgaltm1Bll
Genetic
Background		 B6.129S7-Itgaltm1Bll/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Bll mutation (2 available); any Itgal mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal inflammatory response ( J:113463 )
• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice fail to exhibit 20% less hemorrhage and 12% less accumulation of neutrophils compared to the thrombohemorrhagic vasculitis observed in wild type mice




Genotype
MGI:3817277
hm3
Allelic
Composition		 Itgaltm1Bll/Itgaltm1Bll
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Bll mutation (2 available); any Itgal mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cellular extravasation ( J:141063 )
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
abnormal leukocyte adhesion ( J:141063 )
• leukocytes from these mutant mice fail to have enhanced adhesion to endothelial cells lacking Edil3 (Del-1) expression
abnormal neutrophil physiology ( J:141063 )
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
abnormal CD4-positive, alpha-beta T cell physiology ( J:267548 )
• reduced adhesion of CD4+ T cells to mICAM-1-Fc-coated plates before and after transfection with V5G+ T cell microvilli particles

cellular
abnormal cellular extravasation ( J:141063 )
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
abnormal leukocyte adhesion ( J:141063 )
• leukocytes from these mutant mice fail to have enhanced adhesion to endothelial cells lacking Edil3 (Del-1) expression

hematopoietic system
abnormal cellular extravasation ( J:141063 )
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
abnormal leukocyte adhesion ( J:141063 )
• leukocytes from these mutant mice fail to have enhanced adhesion to endothelial cells lacking Edil3 (Del-1) expression
abnormal neutrophil physiology ( J:141063 )
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
abnormal CD4-positive, alpha-beta T cell physiology ( J:267548 )
• reduced adhesion of CD4+ T cells to mICAM-1-Fc-coated plates before and after transfection with V5G+ T cell microvilli particles




Genotype
MGI:2661084
hm4
Allelic
Composition		 Itgaltm1Bll/Itgaltm1Bll
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Bll mutation (2 available); any Itgal mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte migration ( J:83226 )
• leukocyte influx in a subcutaneous air pouch in response to TNF-alpha is reduced by 67%
abnormal cellular extravasation ( J:83226 )
• neutrophil extravasation in response to TNF-alpha is dramatically decreased
abnormal leukocyte adhesion ( J:83226 )
• adhesion of neutrophils to ICAM-1 or endothelial cells is not increased with Zas stimulation as observed with wild-type neutrophils
• however, normal adhesion of neutrophils to fibrinogen and KLH
• activated neutrophils show a substantial decrease in adhesion in response to shear stress
increased leukocyte cell number ( J:83226 )
• leukocytosis but do not develop spontaneous infections

hematopoietic system
abnormal leukocyte migration ( J:83226 )
• leukocyte influx in a subcutaneous air pouch in response to TNF-alpha is reduced by 67%
abnormal cellular extravasation ( J:83226 )
• neutrophil extravasation in response to TNF-alpha is dramatically decreased
abnormal leukocyte adhesion ( J:83226 )
• adhesion of neutrophils to ICAM-1 or endothelial cells is not increased with Zas stimulation as observed with wild-type neutrophils
• however, normal adhesion of neutrophils to fibrinogen and KLH
• activated neutrophils show a substantial decrease in adhesion in response to shear stress
increased leukocyte cell number ( J:83226 )
• leukocytosis but do not develop spontaneous infections

cellular
abnormal leukocyte migration ( J:83226 )
• leukocyte influx in a subcutaneous air pouch in response to TNF-alpha is reduced by 67%
abnormal cellular extravasation ( J:83226 )
• neutrophil extravasation in response to TNF-alpha is dramatically decreased
abnormal leukocyte adhesion ( J:83226 )
• adhesion of neutrophils to ICAM-1 or endothelial cells is not increased with Zas stimulation as observed with wild-type neutrophils
• however, normal adhesion of neutrophils to fibrinogen and KLH
• activated neutrophils show a substantial decrease in adhesion in response to shear stress




Genotype
MGI:6367662
ht5
Allelic
Composition		 Itgaltm1Bll/Itgal+
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgaltm1Bll mutation (2 available); any Itgal mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:267548 )
• reduced adhesion of CD4+ T cells to mICAM-1-Fc-coated plates before and after transfection with V5G+ T cell microvilli particles

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:267548 )
• reduced adhesion of CD4+ T cells to mICAM-1-Fc-coated plates before and after transfection with V5G+ T cell microvilli particles




Genotype
MGI:3817278
cx6
Allelic
Composition		 Edil3tm1Tq/Edil3tm1Tq
Itgaltm1Bll/Itgaltm1Bll
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3tm1Tq mutation (0 available); any Edil3 mutation (43 available)
Itgaltm1Bll mutation (2 available); any Itgal mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cellular extravasation ( J:141063 )
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
abnormal neutrophil physiology ( J:141063 )
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

cellular
abnormal cellular extravasation ( J:141063 )
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice

hematopoietic system
abnormal cellular extravasation ( J:141063 )
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice
abnormal neutrophil physiology ( J:141063 )
• mice have lower accumulation of neutrophils in the bronchoalveolar lavage fluid after LPS administration compared to wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory