Analysis Tools
immune system
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• after antigen challenge, there are significantly lower numbers of eosinophils recruited to the nasal submucosa in mutants compared to wild-type mice
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• in sensitized mutants, there is a lower level of TNFalpha in the nasal mucosa compared to sensitized wild-type; as well, levels of IL-4 and IL-5 are lower than in wild-type
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• in OVA sensitized wild-type and mutant mice, OVA challenge results in 2.5 and 16 fold increases respectively in the number of nasal rubs on day 31, compared to control mice
• OVA challenge results in an increase in the number of sneezes only in sensitized wild-type mice on day 29 and 31, not in mutants
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hematopoietic system
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• after antigen challenge, there are significantly lower numbers of eosinophils recruited to the nasal submucosa in mutants compared to wild-type mice
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hearing/vestibular/ear
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• the number of outer cochlear hair cells is aged mice is decreased
• a slight loss of outer hair cells is seen in the middle turn and the basal turn at 1 month of age
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• the stereocilia of the remaining outer cochlear hair cells are damaged
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• 9, 12, and 18 month old mice exhibit increased hearing threshold compared to wild-type mice
• however, no differences in hearing levels are seen at 1, 3, and 6 months of age by click-evoked ABR
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• hearing loss at 9, 12, and 18 months of age
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nervous system
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• the number of outer cochlear hair cells is aged mice is decreased
• a slight loss of outer hair cells is seen in the middle turn and the basal turn at 1 month of age
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• the stereocilia of the remaining outer cochlear hair cells are damaged
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• the number of spiral ganglion cells is lower
• the stria vascularis and spiral ligament appear normal
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