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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(ACTB-Mgat3)2Nta
transgene insertion 2, Naoyuki Taniguchi
MGI:2662357
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(ACTB-Mgat3)2Nta/0 involves: C57BL/6 * DBA/2 MGI:2662360


Genotype
MGI:2662360
tg1
Allelic
Composition		 Tg(ACTB-Mgat3)2Nta/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
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See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:80227 )
• delayed hematopoietic recovery following bone marrow transplantation
• number of CFU-mix (hemoprogenitors), CFU-GM (myeloid progenitors) and BFU-E (erythroid precursors) are decreased in bone marrow and spleen
• bone marrow stromal cells show decreased non-adherent cell production in culture, indicating dysfunction of stroma-dependent hemopoiesis
decreased erythrocyte cell number ( J:80227 )
• in peripheral blood
thrombocytopenia ( J:80227 )
• in peripheral blood
decreased leukocyte cell number ( J:80227 )
• in peripheral blood
pancytopenia ( J:80227 )
• peripheral blood hematology indicates pancytopenia
• pancytopenia following bone marrow transplantation
decreased spleen B cell follicle number ( J:80227 )
• decrease in follicle numbers and in follicle diameter

immune system
decreased leukocyte cell number ( J:80227 )
• in peripheral blood
decreased spleen B cell follicle number ( J:80227 )
• decrease in follicle numbers and in follicle diameter

skeleton
abnormal bone marrow morphology ( J:80227 )
• hypoplastic bone marrow
• bone marrow stromal cells show decreased non-adherent cell production in culture, indicating dysfunction of stroma-dependent hemopoiesis




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory