All Phenotypes Slit3<tm1.1Dor> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slit3^tm1.1Dor
targeted mutation 1.1, David M Ornitz
MGI:2662358

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slit3^tm1.1Dor/Slit3^tm1.1Dor	involves: 129S1/Sv * C57BL/6	MGI:5562646
hm2	Slit3^tm1.1Dor/Slit3^tm1.1Dor	involves: 129S1/Sv * C57BL/6J	MGI:2662361
cn3	Ndst1^tm1Je/Ndst1^tm1Je Slit3^tm1.1Dor/Slit3^tm1.1Dor Tg(Tek-cre)1Ywa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5562649
cn4	Ndst1^tm1Je/Ndst1^tm1Je Slit3^tm1.1Dor/Slit3⁺ Tg(Tek-cre)1Ywa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5562648
cx5	Slit1^tm1.1Matl/Slit1^tm1.1Matl Slit2^tm1Matl/Slit2^tm1Matl Slit3^tm1.1Dor/Slit3⁺	involves: 129S1/Sv * 129S2/SvPas	MGI:3043191
cx6	Slit2^tm1Matl/Slit2^tm1Matl Slit3^tm1.1Dor/Slit3^tm1.1Dor	involves: 129S1/Sv * 129S2/SvPas	MGI:5522767
cx7	Slit1^tm1.1Matl/Slit1^tm1.1Matl Slit2^tm1Matl/Slit2^tm1Matl Slit3^tm1.1Dor/Slit3^tm1.1Dor	involves: 129S1/Sv * 129S2/SvPas	MGI:3043188

Allelic Composition	Slit3^tm1.1Dor/Slit3^tm1.1Dor
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit3^tm1.1Dor mutation (1 available); any Slit3 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:208012 )

• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions

• diaphragmatic tendon vessels show diverse diameters and sprout discontinuity and vascular plexus density are reduced

• vascular density and sprouting in diaphragmatic muscle is reduced

muscle

abnormal diaphragm morphology ( J:208012 )

• vascular density and sprouting in diaphragmatic muscle is reduced

• microvessels in the diaphragm are dilated and disorganized some vessels terminate with large, distended heads with fewer extending filopodia rather than sprouting and communicating with neighboring vessels

• tip endothelial cells are reduced by 89% in diaphragms

abnormal diaphragm central tendon morphology ( J:208012 )

• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions

diaphragmatic hernia ( J:208012 )

• 86% of mice exhibit central tendon congenital diaphragmatic hernia

skeleton

abnormal diaphragm central tendon morphology ( J:208012 )

• vascularization in diaphragmatic tendon is impaired, especially in the anterior tendon regions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital diaphragmatic hernia		DOID:3827	OMIM:142340 OMIM:222400 OMIM:610187	J:208012

Allelic Composition	Slit3^tm1.1Dor/Slit3^tm1.1Dor
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit3^tm1.1Dor mutation (1 available); any Slit3 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:83292 )

• phenotype is stated to be identical to that of Slit3^tm1Dor homozygotes; however, no data are presented in J:83292

growth/size/body

decreased body weight ( J:83292 )

muscle

abnormal diaphragm morphology ( J:83292 )

diaphragmatic hernia ( J:83292 )

thin diaphragm muscle ( J:83292 )

liver/biliary system

herniated liver ( J:83292 )

digestive/alimentary system

herniated intestine ( J:83292 )

intestinal obstruction ( J:83292 )

respiratory system

lung hemorrhage ( J:83292 )

atelectasis ( J:83292 )

respiratory distress ( J:83292 )

cardiovascular system

lung hemorrhage ( J:83292 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital diaphragmatic hernia		DOID:3827	OMIM:142340 OMIM:222400 OMIM:610187	J:83292

Allelic Composition	Ndst1^tm1Je/Ndst1^tm1Je Slit3^tm1.1Dor/Slit3^tm1.1Dor Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst1^tm1Je mutation (4 available); any Ndst1 mutation (47 available)
Slit3^tm1.1Dor mutation (1 available); any Slit3 mutation (81 available)
Tg(Tek-cre)1Ywa mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

diaphragmatic hernia ( J:208012 )

• 100% of mice develop central tendon congenital diaphragmatic hernia compared to 57% of conditional Ndst1 homozygotes and 86% of Slit3 homozygotes

Allelic Composition	Ndst1^tm1Je/Ndst1^tm1Je Slit3^tm1.1Dor/Slit3⁺ Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

diaphragmatic hernia ( J:208012 )

• mice develop central tendon congenital diaphragmatic hernia with the same penetrance as seen in single Ndst1 conditional homozygotes

Allelic Composition	Slit1^tm1.1Matl/Slit1^tm1.1Matl Slit2^tm1Matl/Slit2^tm1Matl Slit3^tm1.1Dor/Slit3⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit1^tm1.1Matl mutation (0 available); any Slit1 mutation (70 available)
Slit2^tm1Matl mutation (2 available); any Slit2 mutation (88 available)
Slit3^tm1.1Dor mutation (1 available); any Slit3 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:89780 )

• at E12.5 commissural axons occasionally recross the floor plate, this is never seen in controls

abnormal spinal cord ventral commissure morphology ( J:89780 )

• the ventral commissure (bundle of nerve fibers passing from one side to the other in the spinal cord) appears thicker compared to controls

abnormal spinal cord lateral column morphology ( J:89780 )

• the ventral funiculus (white matter tract) appears reduced in mutants compared to controls

cellular

abnormal axon guidance ( J:89780 )

• at E12.5 commissural axons occasionally recross the floor plate, this is never seen in controls

Allelic Composition	Slit2^tm1Matl/Slit2^tm1Matl Slit3^tm1.1Dor/Slit3^tm1.1Dor
Genetic Background	involves: 129S1/Sv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slit2^tm1Matl mutation (2 available); any Slit2 mutation (88 available)
Slit3^tm1.1Dor mutation (1 available); any Slit3 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased mammary gland epithelial cell proliferation ( J:141875 )

• in mammary gland ducts formed by transplanted mammary anlage

endocrine/exocrine glands

increased mammary gland epithelial cell proliferation ( J:141875 )

• in mammary gland ducts formed by transplanted mammary anlage

abnormal mammary gland duct morphology ( J:141875 )

• mammary gland ducts formed by transplanted mammary anlage display hyperplasticity and organization defects, including mild to severe defects in ductal lumens and disrupted growth control, 100% penetrant phenotype

integument

increased mammary gland epithelial cell proliferation ( J:141875 )

• in mammary gland ducts formed by transplanted mammary anlage

abnormal mammary gland duct morphology ( J:141875 )

Allelic Composition	Slit1^tm1.1Matl/Slit1^tm1.1Matl Slit2^tm1Matl/Slit2^tm1Matl Slit3^tm1.1Dor/Slit3^tm1.1Dor
Genetic Background	involves: 129S1/Sv * 129S2/SvPas

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:89780 )

• at E12.5 commissural axons appear disorganized as they exit the floor plate lacking the typical bundled morphology

• at E12.5 more commissural axons stall and fail to exit the floor plate (78% versus 28% in controls) or recross the floor plate (~20% versus 0% in controls; controls in this study were Slit1^tm1.1Matl homozygotes)

abnormal spinal cord lateral column morphology ( J:89780 )

• the lateral funiculus (white matter tract) is significantly thinner in triple homozygous mutants compared to controls

cellular

abnormal axon guidance ( J:89780 )

• at E12.5 commissural axons appear disorganized as they exit the floor plate lacking the typical bundled morphology

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