About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ica1tm1Mdos
targeted mutation 1, H Michael Dosch
MGI:2662437
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ica1tm1Mdos/Ica1tm1Mdos involves: 129S1/Sv * 129X1/SvJ MGI:3831658
hm2
 		Ica1tm1Mdos/Ica1tm1Mdos NOD.129-Ica1tm1Mdos MGI:2662441
cx3
 		Ica1tm1Mdos/Ica1tm1Mdos
Ica1lem1Jxia/Ica1lem1Jxia 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5806228


Genotype
MGI:3831658
hm1
Allelic
Composition		 Ica1tm1Mdos/Ica1tm1Mdos
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1tm1Mdos mutation (1 available); any Ica1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:83526 )
• mutants have no obvious phenotype and age normally

reproductive system
reproductive system phenotype ( J:233657 )
N
• mice exhibit normal fertility with no significant difference in total, mobile and linear mobile sperm




Genotype
MGI:2662441
hm2
Allelic
Composition		 Ica1tm1Mdos/Ica1tm1Mdos
Genetic
Background		 NOD.129-Ica1tm1Mdos
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1tm1Mdos mutation (1 available); any Ica1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:83526 )
• a subset of females die spontaneously without prodromal symptoms around 4-5 months of age

homeostasis/metabolism
abnormal glucose homeostasis ( J:83526 )
• diabetes develops around 20 weeks of age, 4 weeks later than wild-type NOD mice

immune system
abnormal T cell physiology ( J:83526 )
• mutants fail to generate, even after immunization, cross-reactive T cells that recognize the dominant Tep69 epitope in Ica1, and the ABBOS epitope in BSA
decreased susceptibility to autoimmune diabetes ( J:83526 )
• although mutants develop diabetes at around 20 weeks of age, this is 4 weeks later than wild-type NOD mice
• mutants are resistant to cyclophosphamide-accelerated diabetes

hematopoietic system
abnormal T cell physiology ( J:83526 )
• mutants fail to generate, even after immunization, cross-reactive T cells that recognize the dominant Tep69 epitope in Ica1, and the ABBOS epitope in BSA




Genotype
MGI:5806228
cx3
Allelic
Composition		 Ica1tm1Mdos/Ica1tm1Mdos
Ica1lem1Jxia/Ica1lem1Jxia
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1lem1Jxia mutation (0 available); any Ica1l mutation (25 available)
Ica1tm1Mdos mutation (1 available); any Ica1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:233657 )
• severe reduction in total and mobile sperm number with complete loss of linear mobile sperm
• in cauda epididymis
abnormal acrosome morphology ( J:233657 )
• fragmented or completely lost
absent acrosome ( J:233657 )
• in some sperm
abnormal sperm nucleus morphology ( J:233657 )
• smaller and irregular compared with wild-type sperm
abnormal spermiogenesis ( J:233657 )
• with round nuclei sperm

cellular
oligozoospermia ( J:233657 )
• severe reduction in total and mobile sperm number with complete loss of linear mobile sperm
• in cauda epididymis
abnormal acrosome morphology ( J:233657 )
• fragmented or completely lost
absent acrosome ( J:233657 )
• in some sperm
abnormal sperm nucleus morphology ( J:233657 )
• smaller and irregular compared with wild-type sperm




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory