Phenotypes associated with this allele

• Allele Symbol: Elf3^tm1Pjh
• Allele Name: targeted mutation 1, Paul J Hertzog
• Allele ID: MGI:2662485
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elf3^tm1Pjh/Elf3^tm1Pjh	involves: 129S4/SvJae * C57BL/6	MGI:3688238

Genotype
MGI:3688238

hm1

• Allelic Composition: Elf3^tm1Pjh/Elf3^tm1Pjh
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:76344 )

• by weaning, only about 27% of expected numbers are still alive

embryonic lethality during organogenesis, incomplete penetrance ( J:76344 )

• only about 71% of expected numbers of homozygotes are still alive at E11.5

growth/size/body

decreased body size ( J:76344 )

• smaller than controls during suckling period although normal in size from E11.5 to birth

• after 6 weeks of age, weight gain is normal and mice attain normal size

cachexia ( J:76344 )

• 2-3 days before death, mice begin to display a wasted phenotype, appear malnourished, lethargic, watery diarrhea

behavior/neurological

lethargy ( J:76344 )

• beginning 2-3 days before death

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:76344 )

• reduced numbers of goblet cells producing sialomucin

diarrhea ( J:76344 )

• watery diarrhea in mice that die starting 2-3 days before death

abnormal intestinal epithelium morphology ( J:76344 )

• intestinal endothelium fails to transform from pseudostratified to columnar by E17.5

• formation of villi is delayed and those present are misshapen

• connective tissue under the lamina propria of the villi is disorganized

abnormal enterocyte morphology ( J:76344 )

• absorptive enterocytes are morphologically abnormal

• tightly packed with apical cytoplasmic snouts

• microvilli are short

• increased numbers of mitochondria and ribosomes

cellular

abnormal intestinal goblet cell morphology ( J:76344 )

• reduced numbers of goblet cells producing sialomucin