Phenotypes associated with this allele

• Allele Symbol: Thpo^tm1Mwm
• Allele Name: targeted mutation 1, Mark W Moore
• Allele ID: MGI:2662551
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thpo^tm1Mwm/Thpo^tm1Mwm	involves: 129S2/SvPas * C57BL/6	MGI:2662553
ht2	Thpo^tm1Mwm/Thpo^+	involves: 129S2/SvPas * C57BL/6	MGI:3511522

Genotype
MGI:2662553

hm1

• Allelic Composition: Thpo^tm1Mwm/Thpo^tm1Mwm
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased megakaryocyte cell number ( J:83262 )

• mutant mice displayed a loss of megakaryocytes in the bone marrow: a 10 fold drop in 32N Megakaryocytes and a 5 fold drop in 16N megakaryocytes

thrombocytopenia ( J:83262 )

• an 88% drop in platelet count was noted in homozygous animals

increased mean platelet volume ( J:83262 )

• a significant increase in the volume of remaining platelets was detected: mutant mice registered 8.7 cubic micrometers compared to 4.7 cubic micrometers in control animals; no significant differences were seen in red blood cells, total white blood cells, neutrophils, bands or esinophils from peripheral blood

immune system

immune system phenotype ( J:83262 )

N • size and cellularity of the lymphoid organs was unaffected

Genotype
MGI:3511522

ht2

• Allelic Composition: Thpo^tm1Mwm/Thpo⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

hematopoietic system

thrombocytopenia ( J:83262 )

• a 67% drop in platelet count was noted in heterozygous animals