Phenotypes associated with this allele

• Allele Symbol: Oxt^tm1Ljm
• Allele Name: targeted mutation 1, Louis J Muglia
• Allele ID: MGI:2663036
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oxt^tm1Ljm/Oxt^tm1Ljm	Not Specified	MGI:3603414
cx2	Ptgs1^tm1Unc/Ptgs1^tm1Unc Oxt^tm1Ljm/Oxt^tm1Ljm	involves: 129P2/OlaHsd * C57BL/6	MGI:3603425

Genotype
MGI:3603414

hm1

• Allelic Composition: Oxt^tm1Ljm/Oxt^tm1Ljm
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:50148 )

N • homozygotes display a normal onset and progression of labor

Genotype
MGI:3603425

cx2

• Allelic Composition: Ptgs1^tm1Unc/Ptgs1^tm1Unc; Oxt^tm1Ljm/Oxt^tm1Ljm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

reproductive system

reproductive system phenotype ( J:50148 )

N • at day 19 of gestation, both wild-type and double homozygous mutant corpora lutea exhibit an amorphous cellular morphology and disrupted luteal architecture, suggesting normal luteolysis

delayed parturition ( J:50148 )

♀ • surprisingly, matings of double homozygous deficient males and females exhibit a normal onset of labor at 19.8 +/- 0.5 days of gestation; however, such matings often result in extended labor with some litters delivering over a 2-day period

endocrine/exocrine glands

lactation failure ( J:50148 )

♀ • double homozygous mothers fail to lactate normally; as a result, pups do not survive

homeostasis/metabolism

decreased prostaglandin level ( J:50148 )

• at day 19 of gestation, double homozygotes have uterine PGF2alpha concentrations only 1-3% of those found in wild-type or Oxt^tm1Ljm single homozygotes; ovarian concentrations are also severely reduced

integument

lactation failure ( J:50148 )

♀ • double homozygous mothers fail to lactate normally; as a result, pups do not survive