Phenotypes associated with this allele

• Allele Symbol: Cldn5^tm1Sts
• Allele Name: targeted mutation 1, Shoichiro Tsukita
• Allele ID: MGI:2663040
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cldn5^tm1Sts/Cldn5^tm1Sts	involves: 129S4/SvJae * C57BL/6	MGI:2663043

Genotype
MGI:2663043

hm1

• Allelic Composition: Cldn5^tm1Sts/Cldn5^tm1Sts
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:83341 )

• homozygotes were born in the expected Mendelian ratios and appeared macroscopically normal; however, newborns gradually stopped moving and died within 10 hours after birth

cardiovascular system

impaired blood-brain barrier function ( J:83341 )

• unexpectedly, homozygotes exhibited size-selective loosening of the blood-brain barrier (BBB)

• tracer experiments and MR imaging indicated that the BBB was specifically affected against small molecules (<800 D), but not larger molecules

nervous system

nervous system phenotype ( J:83341 )

N • vasculogenesis and brain histology appeared normal: no signs of bleeding or edema were observed in the brain

N • ultrathin-section electron microscopy revealed no morphological abnormalities in the brain blood vessels

impaired blood-brain barrier function ( J:83341 )

• unexpectedly, homozygotes exhibited size-selective loosening of the blood-brain barrier (BBB)

• tracer experiments and MR imaging indicated that the BBB was specifically affected against small molecules (<800 D), but not larger molecules