Phenotypes associated with this allele

• Allele Symbol: Tg(Plp1-cre/ERT2)1Ueli
• Allele Name: transgene insertion 1, Ueli Suter
• Allele ID: MGI:2663093
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cmtm5^tm1c(KOMP)Wtsi/Cmtm5^tm1c(KOMP)Wtsi Tg(Plp1-cre/ERT2)1Ueli/0	B6.Cg-Cmtm5^tm1c(KOMP)Wtsi Tg(Plp1-cre/ERT2)1Ueli	MGI:7331503
cn2	Septin8^tm1c(EUCOMM)Wtsi/Septin8^tm1c(EUCOMM)Wtsi Tg(Plp1-cre/ERT2)1Ueli/0	B6N.Cg-Septin8^tm1c(EUCOMM)Wtsi Tg(Plp1-cre/ERT2)1Ueli	MGI:5902377
cn3	Pten^tm1Hwu/Pten^tm1Hwu Tg(Plp1-cre/ERT2)1Ueli/0	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:4837112
cn4	Cmtm6^tm1c(EUCOMM)Wtsi/Cmtm6^tm1c(EUCOMM)Wtsi Tg(Plp1-cre/ERT2)1Ueli/0	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * DBA/2	MGI:6511252
cn5	Cdc42^tm1Brak/Cdc42^tm1Brak Tg(Plp1-cre/ERT2)1Ueli/0	involves: C57BL/6 * DBA/2	MGI:5460891
cn6	Fgd4^tm1Ics/Fgd4^tm1Ics Tg(Plp1-cre/ERT2)1Ueli/0	involves: C57BL/6 * DBA/2	MGI:5460888

Genotype
MGI:7331503

cn1

• Allelic Composition: Cmtm5^{tm1c(KOMP)Wtsi}/Cmtm5^{tm1c(KOMP)Wtsi}; Tg(Plp1-cre/ERT2)1Ueli/0
• Genetic Background: B6.Cg-Cmtm5^{tm1c(KOMP)Wtsi} Tg(Plp1-cre/ERT2)1Ueli

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon morphology ( J:327261 )

• adults show pathological appearing axons in optic nerves (axonopathy) 4 months after tamoxifen injection

Genotype
MGI:5902377

cn2

• Allelic Composition: Septin8^{tm1c(EUCOMM)Wtsi}/Septin8^{tm1c(EUCOMM)Wtsi}; Tg(Plp1-cre/ERT2)1Ueli/0
• Genetic Background: B6N.Cg-Septin8^{tm1c(EUCOMM)Wtsi} Tg(Plp1-cre/ERT2)1Ueli
• Cell Lines: EPD0060_3_G04

nervous system

tomacula ( J:236408 )

♂ • in tamoxifen-treated mice

demyelination ( J:236408 )

♂ • tamoxifen-treated mice exhibit reduction in the spetin scaffold in mature myelin compared with control mice

Genotype
MGI:4837112

cn3

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(Plp1-cre/ERT2)1Ueli/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

nervous system

abnormal brain white matter morphology ( J:161841 )

• mice treated with tamoxifen to induce cre-recombination exhibit an increase in white matter volume

abnormal corpus callosum morphology ( J:161841 )

• many axons in the corpus callosum are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination

abnormal myelin sheath morphology ( J:161841 )

• increase in myelin sheath thickness

• outfoldings of the myelin sheaths in CNS and PNS are observed

abnormal optic nerve morphology ( J:161841 )

• axons in the optic nerve are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination

hypermyelination ( J:161841 )

• many axons in the corpus callosum and optic nerve are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination

• normally nonmyelinated C-fiber axons are spirally enwrapped by Remak Schwann cells are seen in mice treated with tamoxifen to induce cre-recombination

vision/eye

abnormal optic nerve morphology ( J:161841 )

• axons in the optic nerve are hypermyelinated when mice are treated with tamoxifen to induce cre-recombination

Genotype
MGI:6511252

cn4

• Allelic Composition: Cmtm6^{tm1c(EUCOMM)Wtsi}/Cmtm6^{tm1c(EUCOMM)Wtsi}; Tg(Plp1-cre/ERT2)1Ueli/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * DBA/2

nervous system

abnormal axon morphology ( J:296495 )

• increased diameter of sciatic nerve axons 2 and 6 months after treatment with tamoxifen at age 2 months

Genotype
MGI:5460891

cn5

• Allelic Composition: Cdc42^tm1Brak/Cdc42^tm1Brak; Tg(Plp1-cre/ERT2)1Ueli/0
• Genetic Background: involves: C57BL/6 * DBA/2

nervous system

abnormal myelin sheath morphology ( J:190437 )

• mutants injected with tamoxifen at 10 weeks of age exhibit prominent myelin foldings in sciatic nerves

Genotype
MGI:5460888

cn6

• Allelic Composition: Fgd4^tm1Ics/Fgd4^tm1Ics; Tg(Plp1-cre/ERT2)1Ueli/0
• Genetic Background: involves: C57BL/6 * DBA/2

nervous system

abnormal myelin sheath morphology ( J:190437 )

• mutants injected with tamoxifen exhibit aberrant myelin in peripheral nerves at 30 weeks of age