All Phenotypes Notch2<tm2Hhi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Notch2^tm2Hhi
targeted mutation 2, Hisamaru Hirai
MGI:2663711

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch2^tm2Hhi/Notch2^tm2Hhi	involves: C57BL/6 * CBA	MGI:2663715
cn2	Cd19^tm1(cre)Cgn/Cd19⁺ Notch2^tm2Hhi/Notch2^tm1.1Hhi	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:2663723
cn3	Notch2^tm2Hhi/Notch2^tm1.1Hhi Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:2663720

Allelic Composition	Notch2^tm2Hhi/Notch2^tm2Hhi
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2^tm2Hhi mutation (1 available); any Notch2 mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:83476 )

• mutant embryos die around E11.5

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Notch2^tm2Hhi/Notch2^tm1.1Hhi
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Notch2^tm1.1Hhi mutation (1 available); any Notch2 mutation (99 available)
Notch2^tm2Hhi mutation (1 available); any Notch2 mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased transitional stage B cell number ( J:83476 )

• decrease in the number of T2 B cells

• almost complete absence of CD1d T2 B cells, the precursors of marginal zone B cells (pre-MZB)

abnormal spleen marginal zone morphology ( J:83476 )

• complete absence of the perifollicular rim consisting of IgM^hiIgD^lo cells in the spleen

absent marginal zone B cells ( J:83476 )

• near complete absence of marginal zone B cells in the spleen

immune system

decreased transitional stage B cell number ( J:83476 )

• decrease in the number of T2 B cells

• almost complete absence of CD1d T2 B cells, the precursors of marginal zone B cells (pre-MZB)

abnormal spleen marginal zone morphology ( J:83476 )

• complete absence of the perifollicular rim consisting of IgM^hiIgD^lo cells in the spleen

absent marginal zone B cells ( J:83476 )

• near complete absence of marginal zone B cells in the spleen

Allelic Composition	Notch2^tm2Hhi/Notch2^tm1.1Hhi Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2^tm1.1Hhi mutation (1 available); any Notch2 mutation (99 available)
Notch2^tm2Hhi mutation (1 available); any Notch2 mutation (99 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased marginal zone B cell number ( J:83476 )

• reduced number of marginal zone B cells in the spleen

immune system

immune system phenotype ( J:83476 )

N	• mutants exhibit normal T cell development

decreased marginal zone B cell number ( J:83476 )

• reduced number of marginal zone B cells in the spleen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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