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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ahrtm2Bra
targeted mutation 2, Christopher A Bradfield
MGI:2663776
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ahrtm2Bra/Ahrtm2Bra involves: 129/Sv * C57BL/6 MGI:2663777


Genotype
MGI:2663777
hm1
Allelic
Composition		 Ahrtm2Bra/Ahrtm2Bra
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahrtm2Bra mutation (0 available); any Ahr mutation (112 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased heart weight ( J:83597 )
• moderate increase in heart weight

liver/biliary system
decreased liver weight ( J:83597 )
• reduction in liver weight (27% less than wild-type)

hematopoietic system
increased spleen weight ( J:83597 )
• moderate increase in spleen weight

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:83597 )
• resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced toxicity; mutants do not exhibit hepatomegaly, thymic involution or cleft palate formation in response to TCDD administration as seen in controls

immune system
increased spleen weight ( J:83597 )
• moderate increase in spleen weight

cellular

growth/size/body
increased heart weight ( J:83597 )
• moderate increase in heart weight
increased spleen weight ( J:83597 )
• moderate increase in spleen weight




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory