Phenotypes associated with this allele

• Allele Symbol: Socs3^tm2Wsa
• Allele Name: targeted mutation 2, Warren S Alexander
• Allele ID: MGI:2663917
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Socs3^tm1Wsa/Socs3^tm2Wsa Lyz2^tm1(cre)Ifo/?	involves: 129P2/OlaHsd * C57BL/6	MGI:4430241
cn2	Socs3^tm1Wsa/Socs3^tm2Wsa Tg(Vav1-cre)1Awr/0	involves: C57BL/6	MGI:3043869
cn3	Socs3^tm1Wsa/Socs3^tm2Wsa Tg(Alb1-cre)1Dlr/0	involves: C57BL/6 * FVB/N	MGI:4430246

Genotype
MGI:4430241

cn1

• Allelic Composition: Socs3^tm1Wsa/Socs3^tm2Wsa; Lyz2^tm1(cre)Ifo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:83645 )

• macrophages stimulated with macrophage colony-stimulating factor (M-CSF) in the presence of IL-6, but not IFN-gamma, show an increase in the inhibition of proliferation compared to controls, indicating that cells are hyperresponsive to IL-6 but not IFN-gamma

hematopoietic system

abnormal macrophage physiology ( J:83645 )

• macrophages stimulated with macrophage colony-stimulating factor (M-CSF) in the presence of IL-6, but not IFN-gamma, show an increase in the inhibition of proliferation compared to controls, indicating that cells are hyperresponsive to IL-6 but not IFN-gamma

Genotype
MGI:3043869

cn2

• Allelic Composition: Socs3^tm1Wsa/Socs3^tm2Wsa; Tg(Vav1-cre)1Awr/0
• Genetic Background: involves: C57BL/6

hematopoietic system

enlarged spleen ( J:89785 )

• splenomegaly in aged mice which is further enhanced by G-CSF injection

abnormal definitive hematopoiesis ( J:89785 )

• hematopoiesis is perturbed after 17 weeks of age

abnormal erythropoiesis ( J:89785 )

• erythropoiesis is diminished in the bone marrow but increases in the spleen

abnormal myelopoiesis ( J:89785 )

• increased myelopoiesis in the bone marrow

• cells from the neutrophilic granulocyte lineage, when stimulated with G-CSF, show an increase in cloning frequency, survival, and proliferative capacity

• myeloid cells are hyperresponsive to G-CSF and exhibit increased proliferation and survival upon stimulation

abnormal granulocyte differentiation ( J:89785 )

• abnormalities in G-CSF-induced emergency granulocyte production; mutants injected with G-CSG exhibit enhanced neutrophilia, progenitor cell mobilization, and splenomegaly, and develop inflammatory neutrophil infiltration into multiple tissues and hind-leg paresis

extramedullary hematopoiesis ( J:89785 )

• splenomegaly with prominent extramedullary hematopoiesis

• splenomegaly is enhanced by injection with G-CSF

increased neutrophil cell number ( J:89785 )

• mutants develop neutrophilia in adulthood

• neutrophilia is enhanced by injection with granulocyte colony-stimulating factor (G-CSF)

abnormal hematopoietic stem cell morphology ( J:89785 )

• hematopoietic progenitors show enhanced G-CSF and IL-6 induced colony formation

• G-CSF responsive progenitor cells generate higher proportions of macrophage and granulocyte-macrophage colonies than control cells

immune system

enlarged spleen ( J:89785 )

• splenomegaly in aged mice which is further enhanced by G-CSF injection

abnormal myelopoiesis ( J:89785 )

• increased myelopoiesis in the bone marrow

• cells from the neutrophilic granulocyte lineage, when stimulated with G-CSF, show an increase in cloning frequency, survival, and proliferative capacity

• myeloid cells are hyperresponsive to G-CSF and exhibit increased proliferation and survival upon stimulation

abnormal granulocyte differentiation ( J:89785 )

• abnormalities in G-CSF-induced emergency granulocyte production; mutants injected with G-CSG exhibit enhanced neutrophilia, progenitor cell mobilization, and splenomegaly, and develop inflammatory neutrophil infiltration into multiple tissues and hind-leg paresis

increased neutrophil cell number ( J:89785 )

• mutants develop neutrophilia in adulthood

• neutrophilia is enhanced by injection with granulocyte colony-stimulating factor (G-CSF)

increased inflammatory response ( J:89785 )

• mutants develop an inflammatory disease after 17 weeks of age characterized by inflammation in the pleural and peritoneal cavities, neutrophil leukocytosis, and infiltration of liver and lungs by hematopoietic cells from multiple lineages

peritoneal inflammation ( J:89785 )

liver inflammation ( J:89785 )

• infiltration of liver by hematopoietic cells from multiple lineages

lung inflammation ( J:89785 )

• infiltration of the lungs by hematopoietic cells from multiple lineages

digestive/alimentary system

peritoneal inflammation ( J:89785 )

liver/biliary system

liver inflammation ( J:89785 )

• infiltration of liver by hematopoietic cells from multiple lineages

respiratory system

lung inflammation ( J:89785 )

• infiltration of the lungs by hematopoietic cells from multiple lineages

cellular

abnormal granulocyte differentiation ( J:89785 )

• abnormalities in G-CSF-induced emergency granulocyte production; mutants injected with G-CSG exhibit enhanced neutrophilia, progenitor cell mobilization, and splenomegaly, and develop inflammatory neutrophil infiltration into multiple tissues and hind-leg paresis

growth/size/body

enlarged spleen ( J:89785 )

• splenomegaly in aged mice which is further enhanced by G-CSF injection

Genotype
MGI:4430246

cn3

• Allelic Composition: Socs3^tm1Wsa/Socs3^tm2Wsa; Tg(Alb1-cre)1Dlr/0
• Genetic Background: involves: C57BL/6 * FVB/N

normal phenotype

no abnormal phenotype detected ( J:83645 )

• mice develop normally, are healthy and fertile, and liver function appears normal