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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Socs3tm2.1Wsa
targeted mutation 2.1, Warren S Alexander
MGI:2663925
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Socs3tm2.1Wsa/Socs3tm2.1Wsa involves: C57BL/6 MGI:2663929
ht2
 		Socs3tm1Wsa/Socs3tm2.1Wsa involves: C57BL/6 MGI:4430248


Genotype
MGI:2663929
hm1
Allelic
Composition		 Socs3tm2.1Wsa/Socs3tm2.1Wsa
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3tm2.1Wsa mutation (0 available); any Socs3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal placenta morphology ( J:83645 )
• a placental defect is seen at E12-13




Genotype
MGI:4430248
ht2
Allelic
Composition		 Socs3tm1Wsa/Socs3tm2.1Wsa
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3tm1Wsa mutation (0 available); any Socs3 mutation (22 available)
Socs3tm2.1Wsa mutation (0 available); any Socs3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:83645 )
• die at E13.5 due to placental insufficiency

embryo
increased trophoblast giant cell number ( J:83645 )
• placenta at E12.5 shows expansion of trophoblast giant cells
absent spongiotrophoblast ( J:83645 )
• spongiotrophoblast is absent at E12.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory