Phenotypes associated with this allele

• Allele Symbol: Bcl11a^tm1Ngc
• Allele Name: targeted mutation 1, Neal G Copeland
• Allele ID: MGI:2663941
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl11a^tm1Ngc/Bcl11a^tm1Ngc	involves: 129S1/Sv * C57BL/6J	MGI:2663942
ht2	Bcl11a^tm1Ngc/Bcl11a^+	involves: 129S1/Sv	MGI:5475384

Genotype
MGI:2663942

hm1

• Allelic Composition: Bcl11a^tm1Ngc/Bcl11a^tm1Ngc
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:83646 )

• mutant animals die 3-4 hours after birth

cellular

abnormal dendritic cell differentiation ( J:207383 )

• reduction in plasmacytoid dendritic cell differentiation but not conventional dendritic cell differentiation from E18 liver cells in vitro

immune system

abnormal dendritic cell differentiation ( J:207383 )

• reduction in plasmacytoid dendritic cell differentiation but not conventional dendritic cell differentiation from E18 liver cells in vitro

small thymus ( J:83646 )

• seen in about 1/3 of embryos

thymus hypoplasia ( J:83646 )

abnormal immunoglobulin heavy chain V(D)J recombination ( J:83646 )

• productive diversity(D)-joining (J) recombination at the Igh locus, which begins at the pro-B cell stage, does not occur

increased double-negative T cell number ( J:83646 )

decreased plasmacytoid dendritic cell number ( J:207383 )

• in E18 liver and spleen cells

absent B cells ( J:83646 , J:207383 )

• few, if any, B220+IgM+, B220+IgM-, B220+CD19+, or B220+CD43+ cells are detected in fetal livers, indicating lack of B cells (J:83646)

• loss of B220+ B lymphocytes in E17 liver and spleen (J:207383)

increased CD8-positive, alpha-beta T cell number ( J:83646 )

• increase in the population of CD4^lowCD8+ cells, most probably reflecting immature CD8+ single-positive thymocytes

increased gamma-delta T cell number ( J:83646 )

• 3- to 4-fold increase in the number of TCRgammadelta thymocytes

decreased T cell number ( J:83646 )

• decrease in the number of TCRalphabeta thymocytes

absent CD4-positive, alpha-beta T cells ( J:83646 )

• CD4^hiCD8- thymocytes are absent

absent lymphocyte ( J:207383 )

• loss of B220+ lymphocytes in E17 liver and spleen

hematopoietic system

abnormal dendritic cell differentiation ( J:207383 )

• reduction in plasmacytoid dendritic cell differentiation but not conventional dendritic cell differentiation from E18 liver cells in vitro

small thymus ( J:83646 )

• seen in about 1/3 of embryos

thymus hypoplasia ( J:83646 )

abnormal immunoglobulin heavy chain V(D)J recombination ( J:83646 )

• productive diversity(D)-joining (J) recombination at the Igh locus, which begins at the pro-B cell stage, does not occur

increased double-negative T cell number ( J:83646 )

decreased plasmacytoid dendritic cell number ( J:207383 )

• in E18 liver and spleen cells

absent B cells ( J:83646 , J:207383 )

• few, if any, B220+IgM+, B220+IgM-, B220+CD19+, or B220+CD43+ cells are detected in fetal livers, indicating lack of B cells (J:83646)

• loss of B220+ B lymphocytes in E17 liver and spleen (J:207383)

increased CD8-positive, alpha-beta T cell number ( J:83646 )

• increase in the population of CD4^lowCD8+ cells, most probably reflecting immature CD8+ single-positive thymocytes

increased gamma-delta T cell number ( J:83646 )

• 3- to 4-fold increase in the number of TCRgammadelta thymocytes

decreased T cell number ( J:83646 )

• decrease in the number of TCRalphabeta thymocytes

absent CD4-positive, alpha-beta T cells ( J:83646 )

• CD4^hiCD8- thymocytes are absent

absent lymphocyte ( J:207383 )

• loss of B220+ lymphocytes in E17 liver and spleen

endocrine/exocrine glands

small thymus ( J:83646 )

• seen in about 1/3 of embryos

thymus hypoplasia ( J:83646 )

Genotype
MGI:5475384

ht2

• Allelic Composition: Bcl11a^tm1Ngc/Bcl11a⁺
• Genetic Background: involves: 129S1/Sv

hematopoietic system

abnormal T cell differentiation ( J:194616 )

• intermediate reduction of T cell progenitors in tamoxifen-treated mice

decreased DN2 thymocyte number ( J:194616 )

• intermediate in tamoxifen-treated mice

abnormal common lymphocyte progenitor cell morphology ( J:194616 )

• intermediate reduced in tamoxifen-treated mice

decreased lymphocyte cell number ( J:207383 )

• decrease in the number of B200<+> lymphocytes in E17 liver and spleen

decreased hematopoietic stem cell number ( J:194616 )

• intermediate reduced of lymphoid-primed multipotent progenitors in tamoxifen-treated mice

immune system

abnormal T cell differentiation ( J:194616 )

• intermediate reduction of T cell progenitors in tamoxifen-treated mice

decreased DN2 thymocyte number ( J:194616 )

• intermediate in tamoxifen-treated mice

decreased lymphocyte cell number ( J:207383 )

• decrease in the number of B200<+> lymphocytes in E17 liver and spleen

endocrine/exocrine glands

decreased DN2 thymocyte number ( J:194616 )

• intermediate in tamoxifen-treated mice