About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(GFAP-TVA)5Hev
transgene insertion 5, Harold E Varmus
MGI:2663943
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(GFAP-TVA)5Hev/0 		involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL MGI:3835356
cx2
 		Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp
Tg(GFAP-TVA)5Hev/0 		involves: 129S6/SvEvTac * BALB/c * C57BL/6 * FVB/N MGI:3835352
cx3
 		Cdkn2atm1Cjs/Cdkn2atm1Cjs
Tg(GFAP-TVA)5Hev/0 		involves: 129X1/SvJ * BALB/c * C57BL/6 * FVB/N MGI:3835355
tg4
 		Tg(GFAP-TVA)5Hev/0 involves: BALB/c * C57BL/6 * FVB/N MGI:3835351


Genotype
MGI:3835356
cx1
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(GFAP-TVA)5Hev/0
Genetic
Background		 involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Tg(GFAP-TVA)5Hev mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:125535 )
• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 30% compared to 85% survival in similarly treated Tg(GFAP-TVA)5Hev mice

neoplasm
increased glioma incidence ( J:125535 )
• 19 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 5 grade II (similar to human oligodendroglioma) and 14 grade III (similar to anaplastic oligodendroglioma) tumors were found

nervous system
increased glioma incidence ( J:125535 )
• 19 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 5 grade II (similar to human oligodendroglioma) and 14 grade III (similar to anaplastic oligodendroglioma) tumors were found




Genotype
MGI:3835352
cx2
Allelic
Composition		 Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp
Tg(GFAP-TVA)5Hev/0
Genetic
Background		 involves: 129S6/SvEvTac * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm2.1Rdp mutation (2 available); any Cdkn2a mutation (67 available)
Tg(GFAP-TVA)5Hev mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:125535 )
• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 25% compared to 85% survival in similarly treated Tg(GFAP-TVA)5Hev mice

neoplasm
increased glioma incidence ( J:125535 )
• 23 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 18 grade II (similar to human oligodendroglioma) and 5 grade III (similar to anaplastic oligodendroglioma)

nervous system
increased glioma incidence ( J:125535 )
• 23 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 18 grade II (similar to human oligodendroglioma) and 5 grade III (similar to anaplastic oligodendroglioma)




Genotype
MGI:3835355
cx3
Allelic
Composition		 Cdkn2atm1Cjs/Cdkn2atm1Cjs
Tg(GFAP-TVA)5Hev/0
Genetic
Background		 involves: 129X1/SvJ * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (7 available); any Cdkn2a mutation (67 available)
Tg(GFAP-TVA)5Hev mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:125535 )
• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 25% compared to 85% survival in similarly treated Tg(GFAP-TVA)5Hev mice

neoplasm
increased glioma incidence ( J:125535 )
• 20 gliomas are discovered in 26 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 3 grade II (similar to human oligodendroglioma) and 17 grade III (similar to anaplastic oligodendroglioma)

nervous system
increased glioma incidence ( J:125535 )
• 20 gliomas are discovered in 26 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 3 grade II (similar to human oligodendroglioma) and 17 grade III (similar to anaplastic oligodendroglioma)




Genotype
MGI:3835351
tg4
Allelic
Composition		 Tg(GFAP-TVA)5Hev/0
Genetic
Background		 involves: BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GFAP-TVA)5Hev mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased glioma incidence ( J:125535 )
• 5 gliomas are discovered in 31 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 5 grade II (similar to human oligodendroglioma)
abnormal glial cell physiology ( J:69971 )
• in mice transfected with replication-competent ALV splice acceptor viral vector expressing bFGF glial cells exhibit increased proliferation and migration compared to similarly treated wild-type cells

neoplasm
increased glioma incidence ( J:125535 )
• 5 gliomas are discovered in 31 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 5 grade II (similar to human oligodendroglioma)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory