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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(GFAP-TVA)5Hev
transgene insertion 5, Harold E Varmus
MGI:2663943
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(GFAP-TVA)5Hev/0 		involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL MGI:3835356
cx2
 		Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp
Tg(GFAP-TVA)5Hev/0 		involves: 129S6/SvEvTac * BALB/c * C57BL/6 * FVB/N MGI:3835352
cx3
 		Cdkn2atm1Cjs/Cdkn2atm1Cjs
Tg(GFAP-TVA)5Hev/0 		involves: 129X1/SvJ * BALB/c * C57BL/6 * FVB/N MGI:3835355
tg4
 		Tg(GFAP-TVA)5Hev/0 involves: BALB/c * C57BL/6 * FVB/N MGI:3835351


Genotype
MGI:3835356
cx1
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2atm1Rdp
Tg(GFAP-TVA)5Hev/0
Genetic
Background		 involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Tg(GFAP-TVA)5Hev mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:125535 )
• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 30% compared to 85% survival in similarly treated Tg(GFAP-TVA)5Hev mice

neoplasm
increased glioma incidence ( J:125535 )
• 19 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 5 grade II (similar to human oligodendroglioma) and 14 grade III (similar to anaplastic oligodendroglioma) tumors were found

nervous system
increased glioma incidence ( J:125535 )
• 19 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 5 grade II (similar to human oligodendroglioma) and 14 grade III (similar to anaplastic oligodendroglioma) tumors were found




Genotype
MGI:3835352
cx2
Allelic
Composition		 Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp
Tg(GFAP-TVA)5Hev/0
Genetic
Background		 involves: 129S6/SvEvTac * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm2.1Rdp mutation (2 available); any Cdkn2a mutation (67 available)
Tg(GFAP-TVA)5Hev mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:125535 )
• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 25% compared to 85% survival in similarly treated Tg(GFAP-TVA)5Hev mice

neoplasm
increased glioma incidence ( J:125535 )
• 23 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 18 grade II (similar to human oligodendroglioma) and 5 grade III (similar to anaplastic oligodendroglioma)

nervous system
increased glioma incidence ( J:125535 )
• 23 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 18 grade II (similar to human oligodendroglioma) and 5 grade III (similar to anaplastic oligodendroglioma)




Genotype
MGI:3835355
cx3
Allelic
Composition		 Cdkn2atm1Cjs/Cdkn2atm1Cjs
Tg(GFAP-TVA)5Hev/0
Genetic
Background		 involves: 129X1/SvJ * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (7 available); any Cdkn2a mutation (67 available)
Tg(GFAP-TVA)5Hev mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:125535 )
• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 25% compared to 85% survival in similarly treated Tg(GFAP-TVA)5Hev mice

neoplasm
increased glioma incidence ( J:125535 )
• 20 gliomas are discovered in 26 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 3 grade II (similar to human oligodendroglioma) and 17 grade III (similar to anaplastic oligodendroglioma)

nervous system
increased glioma incidence ( J:125535 )
• 20 gliomas are discovered in 26 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 3 grade II (similar to human oligodendroglioma) and 17 grade III (similar to anaplastic oligodendroglioma)




Genotype
MGI:3835351
tg4
Allelic
Composition		 Tg(GFAP-TVA)5Hev/0
Genetic
Background		 involves: BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GFAP-TVA)5Hev mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased glioma incidence ( J:125535 )
• 5 gliomas are discovered in 31 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 5 grade II (similar to human oligodendroglioma)
abnormal glial cell physiology ( J:69971 )
• in mice transfected with replication-competent ALV splice acceptor viral vector expressing bFGF glial cells exhibit increased proliferation and migration compared to similarly treated wild-type cells

neoplasm
increased glioma incidence ( J:125535 )
• 5 gliomas are discovered in 31 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB
increased oligodendroglioma incidence ( J:125535 )
• 5 grade II (similar to human oligodendroglioma)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory