Phenotypes associated with this allele

• Allele Symbol: Carm1^tm1Mtb
• Allele Name: targeted mutation 1, Mark T Bedford
• Allele ID: MGI:2663959
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Carm1^tm1Mtb/Carm1^tm1Mtb	involves: 129S6/SvEvTac	MGI:4454545
hm2	Carm1^tm1Mtb/Carm1^tm1Mtb	involves: 129S6/SvEvTac * Black Swiss	MGI:2663966
ht3	Carm1^tm1Mtb/Carm1^+	involves: 129S6/SvEvTac * Black Swiss	MGI:2663975

Genotype
MGI:4454545

hm1

• Allelic Composition: Carm1^tm1Mtb/Carm1^tm1Mtb
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

persistent truncus arteriosus ( J:327081 )

• in E12.5 embryos

double outlet right ventricle ( J:327081 )

• in E18.5 embryos

ventricular septal defect ( J:327081 )

• in E18.5 embryos

hemothorax ( J:327081 )

• bleeding in thoracic cavity in E12.5 embryos

mortality/aging

preweaning lethality, complete penetrance ( J:327081 )

• no mice survive beyond weaning

neonatal lethality, complete penetrance ( J:159958 )

• mice die at birth

adipose tissue

abnormal adipose tissue development ( J:159958 )

• E18.5 mice fail to express a marker of adipogenesis (Thrsp) unlike wild-type mice

respiratory system

hemothorax ( J:327081 )

• bleeding in thoracic cavity in E12.5 embryos

immune system

arrested T cell differentiation ( J:159958 )

• at the DN1 progenitor stage

hematopoietic system

arrested T cell differentiation ( J:159958 )

• at the DN1 progenitor stage

Genotype
MGI:2663966

hm2

• Allelic Composition: Carm1^tm1Mtb/Carm1^tm1Mtb
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:83623 )

• number of mutants is lower than expected (13.5% vs. expected 25%) at E18.5 and E19.5, however normal numbers are seen at E15.5

perinatal lethality, incomplete penetrance ( J:83623 )

• dead pups are found on the day of birth and mutants isolated by Caesarian section fail to breathe, however they do respond to stimulus when pinched with forceps

growth/size/body

decreased fetal size ( J:83623 )

• E18.5 mutants are about 60% smaller than wild-type

respiratory system

abnormal lung morphology ( J:83623 )

• alveolar air spaces are small

respiratory failure ( J:83623 )

• lungs of neonates fail to inflate with air and mutants isolated by Caesarian section fail to breathe

Genotype
MGI:2663975

ht3

• Allelic Composition: Carm1^tm1Mtb/Carm1⁺
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

mortality/aging

postnatal lethality, incomplete penetrance ( J:83623 )

• some loss of pups between birth and weaning