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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fasntm1Schi
targeted mutation 1, Subrahmanyam S Chirala
MGI:2664027
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fasntm1Schi/Fasntm1Schi 129S7/SvEvBrd-Fasntm1Schi MGI:2664054
hm2
 		Fasntm1Schi/Fasntm1Schi involves: 129S7/SvEvBrd * C57BL/6J MGI:2664064
ht3
 		Fasntm1Schi/Fasn+ 129S7/SvEvBrd-Fasntm1Schi MGI:2664056
ht4
 		Fasntm1Schi/Fasn+ involves: 129S7/SvEvBrd * C57BL/6J MGI:2664055


Genotype
MGI:2664054
hm1
Allelic
Composition		 Fasntm1Schi/Fasntm1Schi
Genetic
Background		 129S7/SvEvBrd-Fasntm1Schi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fasntm1Schi mutation (0 available); any Fasn mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:2664064
hm2
Allelic
Composition		 Fasntm1Schi/Fasntm1Schi
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fasntm1Schi mutation (0 available); any Fasn mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:83624 )
• death at the blastocyst stage, most dying before E3.5
• feeding breeders a diet rich in saturated fatty acids does not prevent lethality of homozygotes




Genotype
MGI:2664056
ht3
Allelic
Composition		 Fasntm1Schi/Fasn+
Genetic
Background		 129S7/SvEvBrd-Fasntm1Schi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fasntm1Schi mutation (0 available); any Fasn mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:83624 )
• Background Sensitivity: 60-90% loss of pups on a 129S7/SvEvBrd background




Genotype
MGI:2664055
ht4
Allelic
Composition		 Fasntm1Schi/Fasn+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fasntm1Schi mutation (0 available); any Fasn mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:83624 )
• Background Sensitivity: 60-70% loss of pups on a mixed background involving 129S7/SvEvBrd and C57BL/6J
• feeding breeders a diet rich in saturated fatty acids does not prevent lethality of heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory