Phenotypes associated with this allele

• Allele Symbol: Guca1a/Guca1b^tm1Jnc
• Allele Name: targeted mutation 1, Jeannie Chen
• Allele ID: MGI:2664160
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc	involves: 129S1/Sv * C57BL/6	MGI:3586520
ht2	Guca1a/Guca1b^tm1Jnc/Guca1b^+	involves: 129S1/Sv * C57BL/6	MGI:3586531
cx3	Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc Rcvrn^tm1Clma/Rcvrn^tm1Clma	involves: 129S1/Sv	MGI:3586548
cx4	Cngb1^tm1.1Glf/Cngb1^tm1.1Glf Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc	involves: 129/Sv * 129S1/Sv * C57BL/6	MGI:4881534

Genotype
MGI:3586520

hm1

• Allelic Composition: Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal rod electrophysiology ( J:83914 , J:166744 )

• flash responses from dark-adapted rods are larger and slower than responses from wild-type rods (J:83914)

• mean single photon response amplitude of rods is nearly 5 times larger than in wild-type and the integration time of rod flash responses was 2.5-fold longer than that of wild-type (J:83914)

• flash sensitivity of rods is about 6 times higher and the flash strength required to elicit a half-maximal response is about 8-fold lower (J:83914)

• rod responses display broad rounded peaks lacking the rapid phase or recovery that typically follows the peak in responses of wild-type (J:83914)

• the incremental flash sensitivity of rods fails to be maintained at wild-type levels in bright steady light (J:83914)

• the value of the circulating current in darkness is somewhat larger than that in wild-type rods (J:166744)

• when dark adapted rods are exposed to prolonged steps of light of varying duration the initial rapid decrease in circulating current seen in wild-type rods is absent but a slower current increase is seen and the turning off of light produces a transient overshoot (J:166744)

Genotype
MGI:3586531

ht2

• Allelic Composition: Guca1a/Guca1b^tm1Jnc/Guca1b⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

vision/eye

abnormal eye electrophysiology ( J:83914 )

• flash sensitivities and response kinetics of rods are between those of homozygous Guca1a/Guca1b^tm1Jnc mutant rods and wild-type rods

Genotype
MGI:3586548

cx3

• Allelic Composition: Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc; Rcvrn^tm1Clma/Rcvrn^tm1Clma
• Genetic Background: involves: 129S1/Sv

vision/eye

abnormal eye electrophysiology ( J:99835 )

• reduction in the single photon response amplitude and a corresponding increase in the half-saturating flash strength, and shortened time-to-peak and integration time of the dim flash response when compared to homozygous Guca1a/Guca1b^tm1Jnc mutant mice

Genotype
MGI:4881534

cx4

• Allelic Composition: Cngb1^tm1.1Glf/Cngb1^tm1.1Glf; Guca1a/Guca1b^tm1Jnc/Guca1a/Guca1b^tm1Jnc
• Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

vision/eye

abnormal rod electrophysiology ( J:166744 )

• as in mice homozygous for Guca1a/Guca1b^tm1Jnc alone, flash sensitivity declines more rapidly as a function of background light intensity compared to wild-type mice

• when dark adapted rods are exposed to prolonged steps of light of varying duration the initial rapid decrease in circulating current seen in wild-type rods is absent but a slower current increase is seen and the turning off of light produces a transient overshoot

• the amplitudes of the slow recovery phase and of the overshoot are somewhat larger than in mice homozygous for Guca1a/Guca1b^tm1Jnc alone