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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(PSEN1)1098Citr
transgene insertion 1098, Martin Citron
MGI:2664249
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(PRNP-APPSweInd)8Dwst/0
Tg(PSEN1)1098Citr/0
involves: C3H/HeJ * C57BL/6J * FVB/N MGI:3722166
tg2
Tg(PSEN1)1098Citr/0 B6.FVB-Tg(PSEN1)1098Citr MGI:4356263


Genotype
MGI:3722166
cx1
Allelic
Composition
Tg(PRNP-APPSweInd)8Dwst/0
Tg(PSEN1)1098Citr/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• amyloid deposition is enhanced when the PSEN1 transgene is also expressed by mutants; deposition is noted by 30-45 days of age




Genotype
MGI:4356263
tg2
Allelic
Composition
Tg(PSEN1)1098Citr/0
Genetic
Background
B6.FVB-Tg(PSEN1)1098Citr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice do not exhibit neurodegeneration
• at 8 to 10 months, ramified spine density is decreased 33% compared to in wild-type mice
• at 8 to 10 months and at 13 to 14 months





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory