Phenotypes associated with this allele

• Allele Symbol: Dio3^tm1Stg
• Allele Name: targeted mutation 1, Donald St Germain
• Allele ID: MGI:2664293
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dio3^tm1Stg/Dio3^tm1Stg	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3620674

Genotype
MGI:3620674

hm1

• Allelic Composition: Dio3^tm1Stg/Dio3^tm1Stg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:105434 )

• partial embryonic or perinatal lethality

prenatal lethality, incomplete penetrance ( J:105434 )

• partial embryonic lethality

growth/size/body

postnatal growth retardation ( J:105434 )

• markedly

• weights only 65% of controls at weaning and retardation persists throughout adulthood

• body length proportional to weight

reproductive system

reduced fertility ( J:105434 )

• in both sexes

homeostasis/metabolism

abnormal pituitary hormone level ( J:105434 )

decreased circulating thyroid-stimulating hormone level ( J:105434 )

• undetectable in neonates

increased circulating thyroid-stimulating hormone level ( J:105434 )

• levels normal at weaning

• elevated 50% in adults

abnormal thyroid hormone level ( J:105434 )

decreased circulating thyroxine level ( J:105434 )

• T4 levels barely detectable in newborn

• serum T4 reduced more than 95% at weaning

• adult T4 levels 27% control levels

decreased circulating triiodothyronine level ( J:105434 )

• serum T3 levels reduced 50% at weaning

• adult T3 levels 80% of control levels

increased triiodothyronine level ( J:105434 )

• T3 levels elevated 4 fold at 5 days of age, declining to normal levels at 10 days and continuing to decline to weaning

• serum clearance of T3 is defective

cellular

maternal imprinting ( J:80434 )

• expression is preferentially from the paternal allele