Phenotypes associated with this allele

• Allele Symbol: Prkcq^tm1.1Bai
• Allele Name: targeted mutation 1.1, Gottfried Baier
• Allele ID: MGI:2664377
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkcq^tm1.1Bai/Prkcq^tm1.1Bai	involves: 129P2/OlaHsd * C57BL/6J	MGI:2664378

Genotype
MGI:2664378

hm1

• Allelic Composition: Prkcq^tm1.1Bai/Prkcq^tm1.1Bai
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell physiology ( J:83733 )

• mature CD3+T cells fail to mobilize similar intracellular calcium levels compared to wild-type in response to CD3 crosslinking, however calcium responses stimulated by calcium-ionophore remain intact

• reduction in TCR-induced NFAT activation in T lymphocytes

• TCR-driven production of IP₃ is partially diminished in T cells

decreased T cell proliferation ( J:83733 )

• mature T cells do not proliferate well in response to TCR stimulation (anti-CD3 or anti-CD3/anti-CD28 stimuli)

• the T cell proliferation defect is restored by treatment with PDBu plus calcium ionophore

decreased interleukin-2 secretion ( J:83733 )

• IL-2 secretion is reduced in T cells in response to TCR stimulation (anti-CD3 or anti-CD3/anti-CD28 stimuli)

hematopoietic system

abnormal T cell physiology ( J:83733 )

• mature CD3+T cells fail to mobilize similar intracellular calcium levels compared to wild-type in response to CD3 crosslinking, however calcium responses stimulated by calcium-ionophore remain intact

• reduction in TCR-induced NFAT activation in T lymphocytes

• TCR-driven production of IP₃ is partially diminished in T cells

decreased T cell proliferation ( J:83733 )

• mature T cells do not proliferate well in response to TCR stimulation (anti-CD3 or anti-CD3/anti-CD28 stimuli)

• the T cell proliferation defect is restored by treatment with PDBu plus calcium ionophore

cellular

decreased T cell proliferation ( J:83733 )

• mature T cells do not proliferate well in response to TCR stimulation (anti-CD3 or anti-CD3/anti-CD28 stimuli)

• the T cell proliferation defect is restored by treatment with PDBu plus calcium ionophore