All Phenotypes Hsf2<tm1Miv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsf2^tm1Miv/Hsf2^tm1Miv	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:2673082
cx2	Hsf1^tm1Miv/Hsf1^tm1Miv Hsf2^tm1Miv/Hsf2^tm1Miv	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3033965

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Testes are smaller in Hsf2^tm1Miv/Hsf2^tm1Miv and Hsf1^tm1Miv/Hsf1^tm1Miv Hsf2^tm1Miv/Hsf2^tm1Miv mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:83730 )

• 50% of mice that were liveborn died before 3 weeks of age

prenatal lethality, incomplete penetrance ( J:83730 )

• death between E7.5 and birth, incomplete penetrance

reproductive system

decreased male germ cell number ( J:88035 )

• prepuberal testes contain less spermatogonia or spermatocytes per Sertoli cell

abnormal seminiferous tubule morphology ( J:88035 )

• seminiferous tubules exhibit increased numbers of apoptotic cells

small testis ( J:83730 )

decreased testis weight ( J:88035 )

• testes show reduced weight beginning at 3 weeks of age, with average weight 67% of that of controls, with further reduction to 50% at 4 weeks of age

abnormal spermatogenesis ( J:83730 , J:88035 )

• disrupted (J:83730)

• spermatogenesis is disrupted, with a fraction of seminiferous tubules showing tubular vacuolization (J:88035)

oligozoospermia ( J:83730 , J:88035 )

(J:83730)

• sperm count is reduced by 80% compared to wild-type mice (J:88035)

reduced female fertility ( J:83730 )

decreased litter size ( J:83730 )

nervous system

intracerebral hemorrhage ( J:83730 )

• evident at E9.5 and in liveborn mice that died before 3 weeks of age

dilated lateral ventricle ( J:83730 )

• evident in 33% of mice that survived past 6 weeks of age

dilated third ventricle ( J:83730 )

• evident in 33% of mice that survived past 6 weeks of age

collapsed brain ventricles ( J:83730 )

• collapsed, evident at E9.5

cardiovascular system

intracerebral hemorrhage ( J:83730 )

• evident at E9.5 and in liveborn mice that died before 3 weeks of age

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:88035 )

• seminiferous tubules exhibit increased numbers of apoptotic cells

small testis ( J:83730 )

decreased testis weight ( J:88035 )

• testes show reduced weight beginning at 3 weeks of age, with average weight 67% of that of controls, with further reduction to 50% at 4 weeks of age

cellular

decreased male germ cell number ( J:88035 )

• prepuberal testes contain less spermatogonia or spermatocytes per Sertoli cell

oligozoospermia ( J:83730 , J:88035 )

(J:83730)

• sperm count is reduced by 80% compared to wild-type mice (J:88035)

Allelic Composition	Hsf1^tm1Miv/Hsf1^tm1Miv Hsf2^tm1Miv/Hsf2^tm1Miv
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1^tm1Miv mutation (0 available); any Hsf1 mutation (25 available)
Hsf2^tm1Miv mutation (0 available); any Hsf2 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Testes are smaller in Hsf2^tm1Miv/Hsf2^tm1Miv and Hsf1^tm1Miv/Hsf1^tm1Miv Hsf2^tm1Miv/Hsf2^tm1Miv mice

cellular

azoospermia ( J:88035 )

• total lack of sperm in seminal fluid

multinucleated giant male germ cells ( J:88035 )

arrest of male meiosis ( J:88035 )

• the most advanced germ cells present are spermatogonia and pachytene spermatocytes indicating male meiosis does not progress beyond prophase I

mortality/aging

prenatal lethality, incomplete penetrance ( J:88035 )

• reduced numbers of double homozygotes are born

endocrine/exocrine glands

abnormal testis morphology ( J:88035 )

abnormal seminiferous tubule morphology ( J:88035 )

• large vacuolated structures and large multinucleated giant cells found in tubules

• large numbers of apoptotic cells in tubules of testes

small testis ( J:88035 )

• less than 50% of wild-type

growth/size/body

decreased body size ( J:88035 )

• reduced by about 20% compared to wild-type

decreased body weight ( J:88035 )

• reduced by about 20% compared to wild-type

reproductive system

abnormal testis morphology ( J:88035 )

abnormal seminiferous tubule morphology ( J:88035 )

• large vacuolated structures and large multinucleated giant cells found in tubules

• large numbers of apoptotic cells in tubules of testes

small testis ( J:88035 )

• less than 50% of wild-type

abnormal gametogenesis ( J:88035 )

azoospermia ( J:88035 )

• total lack of sperm in seminal fluid

multinucleated giant male germ cells ( J:88035 )

arrest of male meiosis ( J:88035 )

• the most advanced germ cells present are spermatogonia and pachytene spermatocytes indicating male meiosis does not progress beyond prophase I

abnormal fertility/fecundity ( J:88035 )

female infertility ( J:88035 )

male infertility ( J:88035 )

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