Phenotypes associated with this allele

• Allele Symbol: Nanog^tm1Yam
• Allele Name: targeted mutation 1, Shinya Yamanaka
• Allele ID: MGI:2664492
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nanog^tm1Yam/Nanog^tm1Yam	involves: 129S4/SvJae	MGI:2673004

Genotype
MGI:2673004

hm1

• Allelic Composition: Nanog^tm1Yam/Nanog^tm1Yam
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:83420 )

• no mice homozygous for this allele were born from heterozygous intercrosses

• at E3.5 homozygous embryos are indistinguishable from normal embryos; however, no homozygous embryos were present at E7.5

embryo

absent embryonic epiblast ( J:83420 )

• at E5.5, embryos presumably homozygous had no discernable epiblast

absent extraembryonic ectoderm ( J:83420 )

• at E5.5, embryos presumably homozygous had no extraembryonic ectoderm

disorganized extraembryonic tissue ( J:83420 )

• at E5.5, embryos presumably homozygous were made entirely of disorganized extraembryonic tissue