All Phenotypes Akt2<tm1Rsg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Akt2^tm1Rsg
targeted mutation 1, Robert S Garofalo
MGI:2664498

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akt2^tm1Rsg/Akt2^tm1Rsg	DBA/1LacJ-Akt2^tm1Rsg	MGI:2673750
hm2	Akt2^tm1Rsg/Akt2^tm1Rsg	involves: C57BL/6 * DBA/1LacJ	MGI:3848165
cx3	Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg Pten^tm1Ppp/Pten⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ	MGI:3848161
cx4	Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ	MGI:3848163
cx5	Akt2^tm1Rsg/Akt2^tm1Rsg Pten^tm1Ppp/Pten⁺	involves: 129S1/Sv * C57BL/6 * DBA/1LacJ	MGI:3848162
cx6	Akt1^tm1Nhy/Akt1^tm1Nhy Akt2^tm1Rsg/Akt2^tm1Rsg	involves: 129/Sv * C57BL/6 * DBA/1LacJ	MGI:2673733
cx7	Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg Akt3^tm1Nhy/Akt3^tm1Nhy	involves: 129/Sv * C57BL/6 * DBA/1LacJ	MGI:3848164
cx8	Akt2^tm1Rsg/Akt2^tm1Rsg Akt3^tm1Nhy/Akt3^tm1Nhy	involves: 129/Sv * C57BL/6 * DBA/1LacJ	MGI:3848166

Allelic Composition	Akt2^tm1Rsg/Akt2^tm1Rsg
Genetic Background	DBA/1LacJ-Akt2^tm1Rsg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1Rsg mutation (0 available); any Akt2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased brown adipose tissue mass ( J:84606 )

• reduced 13% in males and 20% in females

decreased white adipose tissue mass ( J:84606 )

• reduced by 50% in females only

• fat depot loss became very great with age in both sexes due to adipocyte cell loss

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:84606 )

• decreased staining for beta cells by 7 weeks but the condition was no worse at 24 weeks

• islet number and size was normal however in hyperinsulinemic mice

• hypoinsulinemic mice had decreased numbers of islets and few beta cells

growth/size/body

decreased body weight ( J:84606 )

• 8% smaller at birth an continuing throughout life

• relative brain and liver weights increased

decreased body length ( J:84606 )

homeostasis/metabolism

abnormal glucose homeostasis ( J:84606 )

hyperglycemia ( J:84606 )

• in both sexes when fasting

• non-fasting - hyperglycemia was less in females than in males

• male levels significant at 5 weeks but not until 10 weeks in females

decreased circulating insulin level ( J:84606 )

• a subset of males became hypoinsulinemic

increased circulating insulin level ( J:84606 )

• in both sexes but increasing with age in males

impaired glucose tolerance ( J:84606 )

• glucose intolerant

insulin resistance ( J:84606 )

Allelic Composition	Akt2^tm1Rsg/Akt2^tm1Rsg
Genetic Background	involves: C57BL/6 * DBA/1LacJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1Rsg mutation (0 available); any Akt2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:149156 )

• mice exhibit increased serum insulin levels compared with wild-type mice

• following glucose injection, mice exhibit a greater increase in serum insulin levels compared with similarly treated wild-type mice

• however, mice treated with a leptin-expressing adenovirus exhibit normal insulin levels

decreased circulating leptin level ( J:149156 )

• mice exhibit decreased serum leptin levels although not as severely as in Akt1^tm1Nhy/Akt1^tm1Nhy Akt2^tm1Rsg/Akt2^tm1Rsg mice without alterations in food intake

impaired glucose tolerance ( J:149156 )

insulin resistance ( J:149156 )

endocrine/exocrine glands

enlarged pancreatic islets ( J:149156 )

Allelic Composition	Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg Pten^tm1Ppp/Pten⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Nhy mutation (0 available); any Akt1 mutation (34 available)
Akt2^tm1Rsg mutation (0 available); any Akt2 mutation (53 available)
Pten^tm1Ppp mutation (0 available); any Pten mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:149156 )

• following glucose injection, mice exhibit a greater increase in serum insulin levels compared with similarly treated wild-type mice

impaired glucose tolerance ( J:149156 )

• mice exhibit impaired glucose tolerance that is not as severe as in Akt1^tm1Nhy/Akt1^tm1Nhy Akt2^tm1Rsg/Akt2^tm1Rsg mice

• however, mice exhibit normal glucose serum levels under normal conditions

endocrine/exocrine glands

enlarged pancreatic islets ( J:149156 )

• compared to in Akt2^tm1Rsg homozygotes

Allelic Composition	Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/1LacJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:149156 )

• the few insulin+ beta cells exhibit reduced insulin production compared to in wild-type mice

• ex-vivo, glucose-stimulated beta-cells produce and secrete less insulin than similarly treated wild-type cells

hyperglycemia ( J:149156 )

• as early as 1 month after birth, mice exhibit a 2- to 3-fold increase in serum glucose level compared with wild-type mice whether fed or fasted

• increased glucose levels cannot be lowered by injection of insulin as in wild-type mice

• however, mice treated with a leptin-expressing adenovirus exhibit normal glucose levels

increased circulating insulin level ( J:149156 )

• mice exhibit increased serum insulin levels compared with wild-type mice that are 3-fold lower than in Akt2^tm1Rsg homozygotes

• however, injection of glucose does not increase serum insulin levels

• however, mice treated with a leptin-expressing adenovirus exhibit normal insulin levels

decreased circulating leptin level ( J:149156 )

impaired glucose tolerance ( J:149156 )

• mice exhibit a diabetic response to glucose challenge

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:149156 )

• fewer insulin+ beta-cells are detected in pancreatic islet cells compared to in wild-type mice or Akt2^tm1Rsg homozygotes

enlarged pancreatic islets ( J:149156 )

• compared to in Akt2^tm1Rsg homozygotes

decreased insulin secretion ( J:149156 )

• the few insulin+ beta cells exhibit reduced insulin production compared to in wild-type mice

• ex-vivo, glucose-stimulated beta-cells produce and secrete less insulin than similarly treated wild-type cells

adipose tissue

decreased white adipose tissue amount ( J:149156 )

decreased percent body fat/body weight ( J:149156 )

Allelic Composition	Akt2^tm1Rsg/Akt2^tm1Rsg Pten^tm1Ppp/Pten⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * DBA/1LacJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1Rsg mutation (0 available); any Akt2 mutation (53 available)
Pten^tm1Ppp mutation (0 available); any Pten mutation (88 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating insulin level ( J:149156 )

• compared to in Akt2^tm1Rsg homozygotes

impaired glucose tolerance ( J:149156 )

• mice exhibit impaired glucose tolerance that is not as severe as in Akt2^tm1Rsg homozygotes

Allelic Composition	Akt1^tm1Nhy/Akt1^tm1Nhy Akt2^tm1Rsg/Akt2^tm1Rsg
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/1LacJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:83741 )

growth/size/body

decreased birth weight ( J:83741 )

• weights of newborns at birth are only about 50% normal

decreased fetal weight ( J:83741 )

• weights of E18.5 embryos are only about 50% normal

homeostasis/metabolism

abnormal lipid homeostasis ( J:83741 )

• adipocyte differentiation is retarded or does not occur

muscle

muscle hypoplasia ( J:83741 )

• individual muscle fibers are markedly reduced

• individual muscle cells are approximately 50% smaller than normal

respiratory system

respiratory distress ( J:83741 )

• newborn homozygotes display labored breathing

skeleton

delayed bone ossification ( J:83741 )

• ossification barely detectable at E14.5

• at E18.5 there was still extensive cranial cartillage as well as in the axial skeleton and limbs

integument

underdeveloped hair follicles ( J:83741 )

• most hair follicles do not develop beyond very early stage

decreased hair follicle number ( J:83741 )

thin epidermis stratum spinosum ( J:83741 )

• spinous layer particularly affected by skin thinning

abnormal keratinocyte morphology ( J:83741 )

• reduced proliferation of basal keratinocytes

translucent skin ( J:83741 )

thin skin ( J:83741 )

• all layers of skin thinner but present

Allelic Composition	Akt1^tm1Nhy/Akt1⁺ Akt2^tm1Rsg/Akt2^tm1Rsg Akt3^tm1Nhy/Akt3^tm1Nhy
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/1LacJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Nhy mutation (0 available); any Akt1 mutation (34 available)
Akt2^tm1Rsg mutation (0 available); any Akt2 mutation (53 available)
Akt3^tm1Nhy mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:149156 )

Allelic Composition	Akt2^tm1Rsg/Akt2^tm1Rsg Akt3^tm1Nhy/Akt3^tm1Nhy
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/1LacJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1Rsg mutation (0 available); any Akt2 mutation (53 available)
Akt3^tm1Nhy mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired glucose tolerance ( J:149156 )

• mice exhibit a diabetic phenotype similar to Akt2^tm1Rsg homozygotes

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