Phenotypes associated with this allele

• Allele Symbol: Tmod2^tm2Hzo
• Allele Name: targeted mutation 2, Huda Y Zoghbi
• Allele ID: MGI:2664502
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmod2^tm2Hzo/Tmod2^tm2Hzo	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2664508

Genotype
MGI:2664508

hm1

• Allelic Composition: Tmod2^tm2Hzo/Tmod2^tm2Hzo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:83752 )

• mutants do not use a spatially biased search strategy to locate the hidden platform in the Morris water maze, spending equal lengths of time in each quadrant and making equivalent number of crossings for each quadrant

decreased startle reflex ( J:83752 )

• impaired startle response

impaired coordination ( J:83752 )

• mutants have a tendency to spend less time on the rotating rod than wild-type, suggesting a mild coordination impairment

nervous system

enhanced long-term potentiation ( J:83752 )

• mutants exhibit enhancement of LTP during the last 30 min of posttetanus

decreased prepulse inhibition ( J:83752 )

• decrease in levels of prepulse inhibition of the acoustic startle response test