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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd33tm1Avrk
targeted mutation 1, Ajit Varki
MGI:2664507
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd33tm1Avrk/Cd33tm1Avrk involves: 129X1/SvJ * C57BL/6 MGI:2668832


Genotype
MGI:2668832
hm1
Allelic
Composition		 Cd33tm1Avrk/Cd33tm1Avrk
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd33tm1Avrk mutation (1 available); any Cd33 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythrocyte cell number ( J:83728 )
• mean erythrocyte count and hematocrit were reduced very slightly

homeostasis/metabolism
increased circulating aspartate transaminase level ( J:83728 )
• the mean concentration of aspartate aminotransaminase was increased

immune system
decreased inflammatory response ( J:83728 )
• slight and inconsistent hyporesponsiveness to casein induced peritonitis
• marginally significant weaker IL-6 response to LPS-induced systemic inflammation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory