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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Men1tm1Zqw
targeted mutation 1, Zhao-Qi Wang
MGI:2664869
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Men1tm1Zqw/Men1tm1Zqw either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) MGI:3590309
ht2
 		Men1tm1Zqw/Men1+ involves: 129/Sv * 129P2/OlaHsd MGI:5009321


Genotype
MGI:3590309
hm1
Allelic
Composition		 Men1tm1Zqw/Men1tm1Zqw
Genetic
Background		 either: (involves: 129/Sv * 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Men1tm1Zqw mutation (2 available); any Men1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:83882 )
• embryos begin to die between E12.5 and E13.5
• no homozygotes survive to E15.5

growth/size/body
decreased embryo size ( J:83882 )
• embryos at E11.5-E12.5 were generally smaller in size than wild-type embryos

embryo
decreased embryo size ( J:83882 )
• embryos at E11.5-E12.5 were generally smaller in size than wild-type embryos
abnormal embryonic tissue morphology ( J:83882 )
• abnormal development of the organ systems including the heart and liver as well as neural tube development
abnormal neural tube closure ( J:83882 )
• abnormal neural tube closure showing a zig-zag pattern and rarely exencephaly
• incomplete closure of the dorsal neural tube amd mild envagination of the overlying ectoderm

cardiovascular system
trabecula carnea hypoplasia ( J:83882 )
• clear myocardial hypotrophy in most embryos resulting in decreased thickness and density of ventricular trabeculations
thin interventricular septum ( J:83882 )
• thinner intraventricular septum
hemorrhage ( J:83882 )
• body hemorrhages or edemas often found between E11.5 and E12.5

nervous system
abnormal neural tube closure ( J:83882 )
• abnormal neural tube closure showing a zig-zag pattern and rarely exencephaly
• incomplete closure of the dorsal neural tube amd mild envagination of the overlying ectoderm
exencephaly ( J:83882 )
• variable penetrance; severe with open and protruding neuro-ectodermal structures of the forebrain and midbrain

liver/biliary system
delayed hepatic development ( J:83882 )
• severe growth retardation in about 42% of embryos
• abnormal organization of the epithelial and hematopoietic compartments with loosened intercellular contacts and nuclear condensation of hematopoietic and epithelial cells
• many apoptotic cells

muscle
trabecula carnea hypoplasia ( J:83882 )
• clear myocardial hypotrophy in most embryos resulting in decreased thickness and density of ventricular trabeculations




Genotype
MGI:5009321
ht2
Allelic
Composition		 Men1tm1Zqw/Men1+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Men1tm1Zqw mutation (2 available); any Men1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased gastrointestinal tumor incidence ( J:85302 )
• gastrointestinal lesions were seen in 8/49 heterozygous mice, mainly situated in the duodenum or at the junction of the glandular stomach and duodenum
• histological examination of gastrointestinal lesions revealed adenomas and carcinomas in the duodenum
increased intestinal adenoma incidence ( J:85302 )
• histological examination of gastrointestinal lesions revealed adenomas in the duodenum
• gastrinomas in the duodenum
increased stomach tumor incidence ( J:85302 )
• histological examination of gastrointestinal lesions revealed adenomas and carcinomas in the glandular stomach
• tumors located in the mucosa of the bodyfunds glandular stomach were composed of uniform cells with scanty cytoplasma and invaded the submucosa layer
• gastrinomas in the glandular stomach
increased gland tumor incidence ( J:85302 )
• in heterozygous mice older than 13 months of age, a high incidence of multiple endocrine tumors was noted, and nearly all mice developed more than one endocrine tumor
increased adrenal gland tumor incidence ( J:85302 )
• histological analysis of 23 glands in homozygous mice showed nodular hyperplasia in two (9%) at 8-12 months of age
• at 13-18 months of age, 7/31 (23%) homozygous mice exhibited nodular hyperplasia
increased adrenal cortical tumor incidence ( J:85302 )
• after 18 months, 28/61 (46%) heterozygous mice developed adenomas or carcinomas in the adrenal cortex
increased adrenal gland adenoma incidence ( J:85302 )
• histological analysis of 23 glands in homozygous mice showed adenomas in three (13%) at 8-12 months of age
• at 13-18 months of age, 4/31 (13%) heterozygous mice developed adrenal adenomas
increased adrenocortical adenoma incidence ( J:85302 )
• after 18 months, heterozygous mice developed adenomas in the adrenal cortex
increased pituitary adenohypophysis tumor incidence ( J:85302 )
• pituitary tumors occur after the age of 18 months and are more common in females (79%)
• 6/15 pituitary tumors showed strong GH immunoreactivity
• however, all pituitary tumors were negative for ACTH staining
increased prolactinoma incidence ( J:85302 )
• 9/15 pituitary tumors showed strong exclusive PRL immunoreactivity
increased parathyroid adenoma incidence ( J:85302 )
• adenomas are first seen at 12 months of age and were detected in 7/17 (41%) heterozygous mice in the 13- to 18-month age group and 21/33 (64%) mice over 19 months
increased thyroid tumor incidence ( J:85302 )
• seen in 4/61 heterozygous mice
increased thyroid carcinoma incidence ( J:85302 )
• thyroid follicular cell hyperplasia localized focally, and solid follicular cell carcinomas contained tumor cells in densely packed nest and forming a few minute follicles
increased mammary gland tumor incidence ( J:85302 )
• 3/36 heterozygous female mice over 18 months of age exhibited mammary gland carcinomas
increased pancreas tumor incidence ( J:85302 )
• islet hyperplasia is seen by eight months of age
• at 8-12 months of age, 15 of 23 (65%) mice contained hyperplastic or dysplastic islets
• in 4/12 islet tumors analyzed, two hormones were expresssed simultaneously, such as insulin and glucagon, or glucagon and gastrin, suggesting a mixed hormone production
increased pancreatic islet cell adenoma incidence ( J:85302 )
• at 8-12 months of age, 5/23 (22%) developed islet adenomas
increased glucagonoma incidence ( J:85302 )
• islet tumors in 6/12 mice showed strong glucagon immunoreactivity, showing alpha-cell tumors or glucagonomas
increased insulinoma incidence ( J:85302 )
• the majority of the islet tumors expressed high levels of insulin and were thus identified as beta-cell insulinomas
increased pancreatic islet cell carcinoma incidence ( J:85302 )
• at 8-12 months of age, 2/23 developed (9%) carcinomas
• 13/34 mice develop islet carcinomas at 13-18 months of age
increased gonad tumor incidence ( J:85302 )
• heterozygous mutant mice developed a high frequency of tumors in the gonad
• 9/12 (75%) male heterozygous mice at 8-12 months of age exhibited gonadal stromal hyperplasia or dysplasia and 3/12 (25%) exhibited stromal cell tumors, with the tumor incidence reaching 59% and 88% in the 13- to 18-month and 19- to 26-month age groups,espectively
increased ovary tumor incidence ( J:85302 )
• 19/44 (43%) of heterozygous females developed ovarian tumors between the ages of 13 and 26 months
• histological analysis of these tumors revealed that all were derived from sex-cord stromal cells, mainly granulosa cells, contained large round nuclei; the follicular structure was largely replaced by the tumor mass, and tumor cells expressed high levels of 3beta-HSD, indicating steroidogenesis in the tumor cells
increased testis tumor incidence ( J:85302 )
• the focal stromal hyperplasia and multinodular tumors were seen and were frequently bilateral, compressed the surrounding seminiferous tubules, resulting in degenerative changes
• testis tumor cells were large and often polygonal, with an abundant granular eosinophilic cytoplasm and a central round nucleus, and occasionally contained lipid pigment and vacuoles
increased Leydig cell tumor incidence ( J:85302 )
• testes of heterozygous mice contained hyperplastic stromal cells and tumors, both with strong 3beta-HSD expression, a marker for Leydig cells

endocrine/exocrine glands
enlarged adrenal glands ( J:85302 )
• an enlargement of adrenal glands, often bilateral, is observed in heterozygous mice
enlarged pituitary gland ( J:85302 )
• enlarged pituitary was often found in heterozygous mice beyond 13 months of age
thyroid gland hyperplasia ( J:85302 )
• seen in 4/61 heterozygous mice
enlarged ovary ( J:85302 )
• a marked increase in ovarian size in heterozygous mice after 13 months of age
enlarged testis ( J:85302 )
• a marked increase in ovarian size in heterozygous mice after 13 months of age
increased gland tumor incidence ( J:85302 )
• in heterozygous mice older than 13 months of age, a high incidence of multiple endocrine tumors was noted, and nearly all mice developed more than one endocrine tumor
increased adrenal gland tumor incidence ( J:85302 )
• histological analysis of 23 glands in homozygous mice showed nodular hyperplasia in two (9%) at 8-12 months of age
• at 13-18 months of age, 7/31 (23%) homozygous mice exhibited nodular hyperplasia
increased adrenal cortical tumor incidence ( J:85302 )
• after 18 months, 28/61 (46%) heterozygous mice developed adenomas or carcinomas in the adrenal cortex
increased adrenal gland adenoma incidence ( J:85302 )
• histological analysis of 23 glands in homozygous mice showed adenomas in three (13%) at 8-12 months of age
• at 13-18 months of age, 4/31 (13%) heterozygous mice developed adrenal adenomas
increased adrenocortical adenoma incidence ( J:85302 )
• after 18 months, heterozygous mice developed adenomas in the adrenal cortex
increased pituitary adenohypophysis tumor incidence ( J:85302 )
• pituitary tumors occur after the age of 18 months and are more common in females (79%)
• 6/15 pituitary tumors showed strong GH immunoreactivity
• however, all pituitary tumors were negative for ACTH staining
increased prolactinoma incidence ( J:85302 )
• 9/15 pituitary tumors showed strong exclusive PRL immunoreactivity
increased parathyroid adenoma incidence ( J:85302 )
• adenomas are first seen at 12 months of age and were detected in 7/17 (41%) heterozygous mice in the 13- to 18-month age group and 21/33 (64%) mice over 19 months
increased thyroid tumor incidence ( J:85302 )
• seen in 4/61 heterozygous mice
increased thyroid carcinoma incidence ( J:85302 )
• thyroid follicular cell hyperplasia localized focally, and solid follicular cell carcinomas contained tumor cells in densely packed nest and forming a few minute follicles
increased mammary gland tumor incidence ( J:85302 )
• 3/36 heterozygous female mice over 18 months of age exhibited mammary gland carcinomas
increased pancreas tumor incidence ( J:85302 )
• islet hyperplasia is seen by eight months of age
• at 8-12 months of age, 15 of 23 (65%) mice contained hyperplastic or dysplastic islets
• in 4/12 islet tumors analyzed, two hormones were expresssed simultaneously, such as insulin and glucagon, or glucagon and gastrin, suggesting a mixed hormone production
increased pancreatic islet cell adenoma incidence ( J:85302 )
• at 8-12 months of age, 5/23 (22%) developed islet adenomas
increased glucagonoma incidence ( J:85302 )
• islet tumors in 6/12 mice showed strong glucagon immunoreactivity, showing alpha-cell tumors or glucagonomas
increased insulinoma incidence ( J:85302 )
• the majority of the islet tumors expressed high levels of insulin and were thus identified as beta-cell insulinomas
increased pancreatic islet cell carcinoma incidence ( J:85302 )
• at 8-12 months of age, 2/23 developed (9%) carcinomas
• 13/34 mice develop islet carcinomas at 13-18 months of age
increased ovary tumor incidence ( J:85302 )
• 19/44 (43%) of heterozygous females developed ovarian tumors between the ages of 13 and 26 months
• histological analysis of these tumors revealed that all were derived from sex-cord stromal cells, mainly granulosa cells, contained large round nuclei; the follicular structure was largely replaced by the tumor mass, and tumor cells expressed high levels of 3beta-HSD, indicating steroidogenesis in the tumor cells
increased testis tumor incidence ( J:85302 )
• the focal stromal hyperplasia and multinodular tumors were seen and were frequently bilateral, compressed the surrounding seminiferous tubules, resulting in degenerative changes
• testis tumor cells were large and often polygonal, with an abundant granular eosinophilic cytoplasm and a central round nucleus, and occasionally contained lipid pigment and vacuoles
increased Leydig cell tumor incidence ( J:85302 )
• testes of heterozygous mice contained hyperplastic stromal cells and tumors, both with strong 3beta-HSD expression, a marker for Leydig cells

nervous system
enlarged pituitary gland ( J:85302 )
• enlarged pituitary was often found in heterozygous mice beyond 13 months of age
increased pituitary adenohypophysis tumor incidence ( J:85302 )
• pituitary tumors occur after the age of 18 months and are more common in females (79%)
• 6/15 pituitary tumors showed strong GH immunoreactivity
• however, all pituitary tumors were negative for ACTH staining
increased prolactinoma incidence ( J:85302 )
• 9/15 pituitary tumors showed strong exclusive PRL immunoreactivity

reproductive system
enlarged ovary ( J:85302 )
• a marked increase in ovarian size in heterozygous mice after 13 months of age
enlarged testis ( J:85302 )
• a marked increase in ovarian size in heterozygous mice after 13 months of age
increased gonad tumor incidence ( J:85302 )
• heterozygous mutant mice developed a high frequency of tumors in the gonad
• 9/12 (75%) male heterozygous mice at 8-12 months of age exhibited gonadal stromal hyperplasia or dysplasia and 3/12 (25%) exhibited stromal cell tumors, with the tumor incidence reaching 59% and 88% in the 13- to 18-month and 19- to 26-month age groups,espectively
increased ovary tumor incidence ( J:85302 )
• 19/44 (43%) of heterozygous females developed ovarian tumors between the ages of 13 and 26 months
• histological analysis of these tumors revealed that all were derived from sex-cord stromal cells, mainly granulosa cells, contained large round nuclei; the follicular structure was largely replaced by the tumor mass, and tumor cells expressed high levels of 3beta-HSD, indicating steroidogenesis in the tumor cells
increased testis tumor incidence ( J:85302 )
• the focal stromal hyperplasia and multinodular tumors were seen and were frequently bilateral, compressed the surrounding seminiferous tubules, resulting in degenerative changes
• testis tumor cells were large and often polygonal, with an abundant granular eosinophilic cytoplasm and a central round nucleus, and occasionally contained lipid pigment and vacuoles
increased Leydig cell tumor incidence ( J:85302 )
• testes of heterozygous mice contained hyperplastic stromal cells and tumors, both with strong 3beta-HSD expression, a marker for Leydig cells

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:85302 )
• gastrointestinal lesions were seen in 8/49 heterozygous mice, mainly situated in the duodenum or at the junction of the glandular stomach and duodenum
• histological examination of gastrointestinal lesions revealed adenomas and carcinomas in the duodenum
increased intestinal adenoma incidence ( J:85302 )
• histological examination of gastrointestinal lesions revealed adenomas in the duodenum
• gastrinomas in the duodenum
increased stomach tumor incidence ( J:85302 )
• histological examination of gastrointestinal lesions revealed adenomas and carcinomas in the glandular stomach
• tumors located in the mucosa of the bodyfunds glandular stomach were composed of uniform cells with scanty cytoplasma and invaded the submucosa layer
• gastrinomas in the glandular stomach

growth/size/body
enlarged ovary ( J:85302 )
• a marked increase in ovarian size in heterozygous mice after 13 months of age

integument
increased mammary gland tumor incidence ( J:85302 )
• 3/36 heterozygous female mice over 18 months of age exhibited mammary gland carcinomas




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11/12/2024
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