Phenotypes associated with this allele

• Allele Symbol: Atp1a2^tm1Kwk
• Allele Name: targeted mutation 1, Kiyoshi Kawakami
• Allele ID: MGI:2664907
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atp1a2^tm1Kwk/Atp1a2^tm1Kwk	involves: 129X1/SvJ * C57BL/6J	MGI:2669619
ht2	Atp1a2^tm1Kwk/Atp1a2^+	involves: 129X1/SvJ * C57BL/6J	MGI:2669633

Genotype
MGI:2669619

hm1

• Allelic Composition: Atp1a2^tm1Kwk/Atp1a2^tm1Kwk
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:83884 )

• homozygous pups die soon after birth

embryo

embryo phenotype ( J:83884 )

N • no gross morphological defects are observed in homozygous embryos

nervous system

abnormal amygdala morphology ( J:83884 )

• extensive neuronal loss is seen in the amygdala of homozygous embryos from E18.5 to birth

abnormal olfactory cortex morphology ( J:83884 )

• extensive neuronal loss is seen in the piriform cortex of embryos from E18.5 to birth

• the nucleus of the lateral olfactory tract was not affected

Genotype
MGI:2669633

ht2

• Allelic Composition: Atp1a2^tm1Kwk/Atp1a2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

behavior/neurological

abnormal fear/anxiety-related behavior ( J:83884 )

• heterozygous mutant mice show increased fear/anxiety behaviors in a variety of tests

• after conditioned fear stimuli, c-fos expression is higher in the amygdala and piriform cortex than in wild-type and unstimulated heterozygous mice