Phenotypes associated with this allele

• Allele Symbol: Ace^tm4Keb
• Allele Name: targeted mutation 4, Kenneth E Bernstein
• Allele ID: MGI:2665017
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ace^tm4Keb/Ace^tm4Keb	involves: 129S1/Sv * 129X1/SvJ	MGI:3720679
cx2	Ace^tm4Keb/Ace^tm4Keb Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	MGI:3720680

Genotype
MGI:3720679

hm1

• Allelic Composition: Ace^tm4Keb/Ace^tm4Keb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

decreased urine osmolality ( J:83894 )

abnormal kidney morphology ( J:83894 )

• renal histology is abnormal

abnormal kidney vasculature morphology ( J:83894 )

• intrarenal arterioles are thickened

kidney medulla hypoplasia ( J:83894 )

abnormal kidney pelvis morphology ( J:83894 )

• the kidney pelvis is widened

decreased kidney weight ( J:83894 )

homeostasis/metabolism

decreased urine osmolality ( J:83894 )

cardiovascular system

abnormal kidney vasculature morphology ( J:83894 )

• intrarenal arterioles are thickened

decreased systemic arterial systolic blood pressure ( J:83894 )

• 74.6+/-2.7 mmHg compared to 121.1+/-4.3 mmHg in wild-type mice

hematopoietic system

decreased hematocrit ( J:83894 )

• hematocrit levels are reduced 41% relative to wild-type mice

Genotype
MGI:3720680

cx2

• Allelic Composition: Ace^tm4Keb/Ace^tm4Keb; Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

renal/urinary system

abnormal kidney vasculature morphology ( J:83894 )

• intrarenal arterioles are thickened as in Ace^tm4Keb homozygotes

kidney cyst ( J:83894 )

• one mouse exhibited a renal cyst similar as those seen in Bdkrb2 null mice

decreased urine osmolality ( J:83894 )

• mice produce less concentrated urine than in wild-type mice and the difference is exacerbated upon water deprivation

decreased kidney weight ( J:83894 )

homeostasis/metabolism

decreased urine osmolality ( J:83894 )

• mice produce less concentrated urine than in wild-type mice and the difference is exacerbated upon water deprivation

abnormal response/metabolism to endogenous compounds ( J:83894 )

• mice do not respond to bradykinin infusion as wild-type mice do by way of reduce blood pressure and increased heart rate

cardiovascular system

abnormal kidney vasculature morphology ( J:83894 )

• intrarenal arterioles are thickened as in Ace^tm4Keb homozygotes

decreased systemic arterial systolic blood pressure ( J:83894 )

• 74.9+/-1.2 mmHg compared to 121.1+/-4.3 mmHg in wild-type mice and similar to that seem in Ace^tm4Keb homozygotes

vascular inflammation ( J:83894 )

• mice present with perivascular inflammation with focal vasculitis

hematopoietic system

decreased hematocrit ( J:83894 )

• hematocrit levels are reduced 45% relative to wild-type mice

growth/size/body

kidney cyst ( J:83894 )

• one mouse exhibited a renal cyst similar as those seen in Bdkrb2 null mice